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Fig. 3 | BMC Cardiovascular Disorders

Fig. 3

From: Interleukin-17 aggravates right ventricular remodeling via activating STAT3 under both normoxia and hypoxia

Fig. 3

IL-17 aggravates hypoxia-induced right ventricular hypertrophy through activating STAT3. A Representative H&E staining of the right ventricular tissue sections derived from mice under normoxia (N4W, n = 7) or hypoxia (H4W, n = 8) for 4 weeks with rmIL-17 (H4W + rmIL-17, n = 6) or not. Scale bars: 50 μm. B Bar chart for cardiomyocytes diameter in the right ventricle of each group. ****p < 0.0001. C Immunofluorescent staining of Bax and caspase-3 of representative histological sections from paraffin-embedded mice right ventricular tissues of each group. Blue for DAPI, red for Bax and caspase-3. Scale bar = 50 μm. D Western blot analysis of p-STAT3 in right ventricular tissue of wide type mice and IL-17 knockout mice (n = 6) and the statistical bar graph. **p = 0.0063

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BMC Cardiovascular Disorders

ISSN: 1471-2261

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