Fig. 1

IL-17 induces right ventricular hypertrophy under normoxia. A Comparison of pulmonary vascular remodeling in mice under conditions of normoxia for 4 weeks (N4W, n = 9) with or without recombinant mouse IL-17 (rmIL-17) (N4W + rmIL-17, n = 9). (a, b) H&E staining of pulmonary arterioles. The arrows show pulmonary arterioles. Scale bars: 50 μm. (c) Percentage medial thicknesses (MT%) of pulmonary arterioles less than 100 μm. B Right ventricular hypertrophy of mice in the groups of N4W and N4W + rmIL-17. (a) RVHI of mice. RVHI: right ventricular hypertrophy index. **p = 0.0053. (b) RV/body weight ratio of mice. *p = 0.0220. C Cardiomyocyte hypertrophy of the right ventricular tissue sections derived from mice in the groups of N4W and N4W + rmIL-17. (a, b) Representative H&E staining. (c) Bar chart for cardiomyocytes diameter in the right ventricle of each group. ****p < 0.0001