Diabetic microvascular complications are associated with reduced global longitudinal strain independent of atherosclerotic coronary artery disease in asymptomatic patients with diabetes mellitus: a cross-sectional study

Table 3 Characteristics of echocardiographic and CCTA parameters stratified by microvascular complications in 222 patients

	No microvascular complications (n = 111)	1 microvascular complications (n = 75)	2–3 microvascular complications (n = 36)	p
Echocardiography
LVEF (%)	56 ± 5	54 ± 6	55 ± 5	ns
GLS (%)	− 16.4 ± 2.5	− 16.0 ± 2.5	− 14.9 ± 2.8	0.01
LAVI (ml/m²)	22 ± 7	23 ± 7	21 ± 5	ns
LVMI (g/m²)	71 ± 23	77 ± 21	71 ± 19	ns
e’ (cm/sec)	0.09 ± 0.02	0.09 ± 0.05	0.08 ± 0.02	0.03
IVRT (msec)	82 ± 20	84 ± 17	83 ± 17	ns
E/e’	9.2 ± 2.9	9.7 ± 3.1	10.0 ± 2.7	ns
E/A	1.1 ± 0.3	1.0 ± 0.3	0.9 ± 0.3	ns
DCT (msec)	221 ± 56	221 ± 53	209 ± 44	ns
Computed tomography
CAC [IQR]	39 [0–239]	22 [0–180]	130 [30–720]	ns*
PB (%)	20 ± 17	22 ± 16	27 ± 18	ns
PB LAD/LM (%)	36 ± 11	35 ± 9	40 ± 11	ns
PB RCA (%)	26 ± 8	27 ± 10	30 ± 11	ns
PB CX (%)	33 ± 12	31 ± 11	37 ± 13	ns

CCTA coronary computed tomography angiography; ns not significant; LVEF left ventricular ejection fraction; GLS global longitudinal strain; LAVI left atrial volume indexed; LVMI left ventricular mass indexed; e’ tissue Doppler average early diastolic mitral annulus velocity; IVRT tissue Doppler average isovolumetric relaxation time; E/é ratio of transmitral Doppler early peak velocity (E) and tissue Doppler average early diastolic mitral annulus velocity (e'); E/A ratio of transmitral Doppler early peak velocity (E) and transmitral Doppler peak late velocity (A); DCT deceleration time; CAC coronary artery calcium; IQR interquartile range; PB plaque burden; LAD/LM left anterior descending coronary artery/left main; RCA right coronary artery; CX circumflex artery
*Comparison of medians between patients with and without microvascular complications

ISSN: 1471-2261