Comparative efficacy of image-guided techniques in cardiac resynchronization therapy: a meta-analysis

Hu, Xiao; Xu, Hai; Hassea, Shameer Raaj Avishkar; Qian, Zhiyong; Wang, Yao; Zhang, Xinwei; Hou, Xiaofeng; Zou, Jiangang

doi:10.1186/s12872-021-02061-y

BMC Cardiovascular Disorders

Table 2 Baseline characteristics of the included studies and patients

From: Comparative efficacy of image-guided techniques in cardiac resynchronization therapy: a meta-analysis

Study	Country	Study design	CRT intervention	Sample size	Age (year)	Gender male (%)	NYHA class	QRS duration (ms)	Definition of response
Bai et al. [15]	United States	Prospective study	Image-guided	50	66 ± 11	60	III or IV: 3.10 ± 0.30	153 ± 23	At least 1 class decrease of NYHA, increase > 20% in LVEF, reduction ≥ 15% in LVESV. fulfill at least 2 of the above 3 criteria
Bai et al. [15]	United States	Prospective study	Standard	54	64 ± 9	74	III or IV: 3.07 ± 0.26	155 ± 29
Khan et al. [16]	United Kingdom	RCT	Image-guided	110	72 (65–76)	77	III/IV:95/15	157 (148–170)	A reduction ≥ 15% in LVESV
Khan et al. [16]	United Kingdom	RCT	Standard	110	72 (64–80)	80	III/IV:93/17	159 (146–170)	A reduction ≥ 15% in LVESV
Saba et al. [17]	United States	RCT	Image-guided	110	66 ± 11	70	II/III/IV:16/64/20	157 ± 27	A reduction ≥ 15% in LVESV or ≥ 5% increase in LVEF with no primary end point (death or first HF hospitalization)
Saba et al. [17]	United States	RCT	Standard	77	67 ± 13	78	II/III/IV:8/71/21	162 ± 27
Sommer et al. [19]	Denmark	RCT	Image-guided	89	71 ± 9	78	II/III/IV:44/44/1	167 ± 22	Improvement in NYHA class, ≥ 10% increase in 6MWT distance, with no death or HF hospitalization
Sommer et al. [19]	Denmark	RCT	Standard	93	71 ± 9	80	II/III/IV:40/48/5	165 ± 22
Mele et al. [22]	Italy	Retrospective study	Image-guided	64	68.4 ± 9.0	77	II/III/IV:47/15/2	153.4 ± 23.6	A reduction > 15% in LVESV
Mele et al. [22]	Italy	Retrospective study	Standard	64	68.4 ± 11.1	86	II/III/IV:37/23/4	155.3 ± 16.1	A reduction > 15% in LVESV
Bertini et al. [18]	Italy	Prospective study	Image-guided	50	67.3 ± 9.7	74	II/III/IV:29/17/4	156 ± 24	A reduction ≥ 15% in LVESV
Bertini et al. [18]	Italy	Prospective study	Standard	50	65.6 ± 8.4	76	II/III/IV:25/24/1	154 ± 30	A reduction ≥ 15% in LVESV
Salden et al. [20]	Netherlands	Prospective study	Image-guided	6	67 ± 3	50	II/III:5/1	165 ± 26	A reduction > 15% in LVESV
Salden et al. [20]	Netherlands	Prospective study	Standard	9	69 ± 9	78	II/III:7/2	160 ± 22	A reduction > 15% in LVESV
Zou et al. [21]	China	RCT	Image-guided	87	62.5 ± 11.5	68	II/III/IV:18/52/17	163.57 ± 23.63	A reduction > 15% in LVESV
Zou et al. [21]	China	RCT	Standard	90	62.7 ± 11.2	72	II/III/IV:18/55/17	161.17 ± 24.16	A reduction > 15% in LVESV

CRT, cardiac resynchronization therapy; LVESV, left ventricular end-systolic volume; LV, left ventricular; EF, ejection fraction; RCT, randomized controlled trial; NYHA, New York Heart Association

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ISSN: 1471-2261

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