Severe, but not mild to moderate, non-alcoholic fatty liver disease associated with increased risk of subclinical coronary atherosclerosis

Table 2 Multivariable logistic regression models of severe NAFLD on the risk of subclinical atherosclerosis in terms of CAC ≧ 100, CAC ≧ 400, CAD-RADS ≧ 3, and presences of vulnerable plaque(s)

	Model 1 (CAC score ≧ 100)			Model 2 (CAC score ≧ 400)			Model 3 (CAD-RADS ≧ 3)			Model 4 (vulnerable plaque)
	OR	CI	p value	OR	CI	p value	OR	CI	p value	OR	CI	p value
Framingham risk score (%)	1.072	1.038–1.106	< 0.0001	1.096	1.041–1.154	< 0.0001	1.071	1.032–1.110	< 0.0001	1.079	1.050–1.108	< 0.0001
Body-fat percentage	1.005	0.968–1.043	0.789	1.016	0.970–1.064	0.504	1.011	0.976–1.048	0.537	0.981	0.943–1.020	0.330
Severe NAFLD^*	2.946	1.017–8.530	0.046	4.402	1.149–16.862	0.031	4.091	1.396–11.993	0.010	2.906	1.107–7.624	0.030

OR odds ratio, CI confidence interval, NAFLD Non-alcoholic fatty liver disease, CAC coronary artery calcium, CAD-RADS the coronary artery disease-reporting and data system
*Reference group normal, mild and moderate NAFLD groups (severe NAFLD vs. reference group)

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