Fig. 4

MIAT silencing hindered ox-LDL-induced cell proliferation, migration and invasion by associating with miR-641. a The effects between MIAT silencing and miR-641 inhibitor on miR-641 expression were revealed by qRT-PCR in ox-LDL-induced VSMCs. b, c The impacts between MIAT absence and miR-641 inhibitor on cell proliferation were determined by cell colony formation and DNA content quantitation assays in ox-LDL-induced VSMCs. d–e The impacts between MIAT knockdown and miR-641 inhibitor on the protein expression of PCNA, Ki-67 and p-FAK were investigated by western blot analysis in ox-LDL-induced VSMCs. f, g Wound-healing and transwell migration assays were employed to disclose the impacts between MIAT silencing and miR-641 inhibitor on cell migration in ox-LDL-induced VSMCs. g Transwell invasion assay was performed to reveal the influences between MIAT knockdown and miR-641 inhibitor on VSMC invasion under ox-LDL treatment. *P < 0.05