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Table 5 Predictors of death or heart failure

From: Natural history and prognostic implications of left ventricular end-diastolic pressure in reperfused ST-segment elevation myocardial infarction: an analysis of the thrombolysis in myocardial infarction (TIMI) II randomized controlled trial

Outcome

HF or death using LVEDP as categorical variable

Univariate analysis

Multivariate analysis

Predictors

Odd ratio

95% CI (P value)

Odd ratio

95% CI (P value)

(a) LVEDP as categorical variable

 Age

1.05

1.03–1.06 (< 0.001)

1.06

1.04–1.08 (< 0.001)

 Female

1.89

1.36–2.6 (< 0.001)

1.4

0.93–2.13 (0.1)

 Anterior MI

2.31

1.75–3.06 (< 0.001)

2.02

1.43–2.84 (< 0.001)

 HTN

1.32

1.01–1.73 (0.04)

0.98

0.69–1.39 (0.9)

 DM

2.38

1.65–3.42 (< 0.001)

1.84

1.17–2.88 (0.008)

 CKD

1.64

1.23–2.18 (0.001)

1.27

0.89–1.83 (0.2)

 LVEF

0.93

0.92–0.94 (< 0.001)

0.94

0.9–0.98 (0.003)

 LVEDV

1.002

0.99–1.006 (0.07)

  

 LVESV

1.01

1.01–1.02 (< 0.001)

0.99

0.97–1.02 (0.9)

 LVEDP ≥ 18 mmHg

2.4

1.8–3.2 (< 0.001)

1.7

1.2–2.4 (0.002)

Outcome

HF or death using LVEDP quartiles

Univariate analysis

Multivariate analysis

Predictors

Hazard ratio

95% CI (P value)

Hazard ratio

95% CI (P value)

(b) LVEDP quartiles

    

 Age

1.04

1.02–1.05 (< 0.001)

1.04

1.03–1.05 (< 0.001)

 Female

1.7

1.3–2.2 (< 0.001)

1.4

1.01–1.9 (0.04)

 Anterior MI

2.1

1.6–2/7 (< 0.001)

1.7

1.3–2.2 (< 0.001)

 HTN

1.2

0.9–1.6 (0.072)

0.9

0.7–1.2 (0.54)

 DM

2

1.5–2.7 (< 0.001)

1.5

1.1–2.1 (0.01)

 CKD

1.5

1.2–1.9 (0.001)

1.2

0.9–1.6 (0.21)

 LVEF

0.94

0.93–0.95 (< 0.001)

0.95

0.93–0.98 (0.001)

 LVEDV

1

0.9–1.01 (0.089)

1

0.9–1.01 (0.45)

 LVESV

1.008

1.006–1.01 (< 0.001)

0.99

0.98–1.01 (0.85)

LVEDP Quartiles (Comparison with quartile 1)

    

 Quartile 2

1.3

0.9–1.8 (0.21)

1.2

0.8–1.8 (0.43)

 Quartile 3

1.7

1.2–2.5 (0.003)

1.4

0.9–2.1 (0.12)

 Quartile 4

3

2.1–4.2 (< 0.001)

1.9

1.3–2.8 (0.001)

  1. DM diabetes mellitus, HTN hypertension, MI myocardial infarction, CI confidence interval, CKD chronic kidney disease, LVEF left ventricular ejection fraction, LVEDV left ventricular end-diastolic volume, LVESV left ventricular end systolic volume, LVEDP left ventricular end-diastolic pressure