Table 1 Patient’s sociodemographic and functional characteristics, morbidity and life expectancy, according to antithrombotic treatment strategy
Characteristics | No treatment | VKAs | DOACs | Antiplatelets | Antiplatelets + anticoagulants | Overall | p value |
|---|---|---|---|---|---|---|---|
No. (%) | 45 (4.7) | 573 (59.6) | 208 (21.6) | 63 (6.6) | 72 (7.5) | 961 (100.0) | – |
Age, median (IQR), years a | 83.0 (74.5–88.0) | 81.0 (75.0–86.0) | 80.0 (74.0–85.0) | 83.0 (76.0–88.0) | 78.0 (70.0–82.8) | 81.0 (75.0–86.0) | 0.001 |
≥ 85 years, n (%) | 19 (42.2) | 175 (30.5) | 56 (26.9) | 27 (42.9) | 11 (15.3) | 288 (30.0) | 0.002 |
Gender, male, n (%) b | 24 (53.3) | 285 (49.7) | 91 (43.8) | 30 (47.6) | 46 (63.9) | 476 (49.5) | 0.059 |
BMI, median (IQR), Kg/m2 a | 24.6 (22.7–27.7) | 28.0 (24.9–31.7) | 27.8 (24.2–31.4) | 26.4 (23.5–30.7) | 29.2 (25.3–33.6) | 27.7 (24.8–31.6) | 0.001 |
Educational level, n (%) b | 0.047 | ||||||
Did not complete compulsory education | 10 (23.8) | 114 (20.9) | 36 (17.9) | 10 (16.9) | 14 (20.0) | 184 (20.0) | |
Primary education | 22 (52.4) | 348 (63.7) | 113 (56.2) | 33 (55.9) | 45 (64.3) | 561 (61.1) | |
Secondary education | 4 (9.5) | 61 (11.2) | 33 (16.4) | 10 (16.9) | 8 (11.4) | 116 (12.6) | |
University or higher | 6 (14.3) | 23 (4.2) | 19 (9.5) | 6 (10.2) | 3 (4.3) | 57 (6.2) | |
Institutionalized, n (%) c | 4 (8.9) | 41 (7.2) | 2 (1.0) | 9 (14.3) | 2 (2.8) | 58 (6.1) | < 0.001 |
Dependence in ADLs, n (%) b | 18 (40.9) | 187 (32.7) | 63 (30.3) | 34 (54.0) | 25 (34.7) | 327 (34.1) | 0.008 |
Barthel index score < 60 (severe/total dependence), n (%) b | 15 (33.3) | 84 (14.7) | 33 (15.9) | 23 (36.5) | 7 (9.7) | 162 (16.9) | < 0.001 |
Charlson index, median (IQR) c | 7.0 (5.5–9.0) | 7.04 (6.0–9.0) | 7.0 (5.0–8.0) | 8.0 (6.0–9.0) | 8.0 (6.0–10.0) | 7.04 (6.0–9.0) | 0.009 |
Cognitive impairment (SPMSQ score), n (%) b | 13 (28.9) | 172 (30.2) | 65 (31.3) | 23 (36.5) | 18 (25.0) | 291 (30.4) | 0.692 |
Score > 7 (severe) | 3 (6.7) | 86 (15.0) | 37 (17.8) | 12 (19.0) | 7 (9.7) | 145 (15.1) | 0.194 |
PROFUND index score, median (IQR)a | 6.0 (1.0–10.5) | 3.0 (0.0–6.0) | 3.0 (0.0–5.8) | 5.0 (0.0–10.0) | 2.0 (0.0–5.0) | 3.0 (0.0–6.0) | < 0.001 |
1-year mortality risk, n (%) b | < 0.001 | ||||||
Low (12.1–14.6%) | 14 (31.1) | 258 (45.0) | 99 (47.6) | 17 (27.0) | 37 (51.4) | 425 (44.2) | |
Low-intermediate (21.5–31.5%) | 10 (22.2) | 191 (33.3) | 72 (34.6) | 17 (27.0) | 24 (33.3) | 314 (32.7) | |
Intermediate-high (45.0–50.0%) | 10 (22.2) | 72 (12.6) | 19 (9.1) | 17 (27.0) | 9 (12.5) | 127 (13.2) | |
High (61.3–68.0%) | 11 (24.4) | 52 (9.1) | 18 (8.7) | 12 (19.0) | 2 (2.8) | 95 (9.9) | |
Life expectancy, n (%) b | < 0.001 | ||||||
≥ 6 months | 34 (75.6) | 522 (91.1) | 196 (94.2) | 53 (84.1) | 68 (94.4) | 873 (90.8) | |
< 6 months | 11 (24.4) | 51 (8.9) | 12 (5.8) | 10 (15.9) | 4 (5.6) | 88 (9.2) |