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Table 2 Characteristics of patients presenting with ACCs

From: Acute cardiac complications and subclinical myocardial injuries associated with pheochromocytoma and paraganglioma

Case

Acute LVEF (%)

Strain analysis

Impairment patterns of LS

Acute global LS

Coronary artery evaluation

Recovery time on imaging

Clinical diagnosis

1

0.38

Yes

Apical ballooning

− 5.5

CTA: (–)

6 days

Takotsubo syndrome

2

0.39

Yes

Apical sparing

− 10.7

CAG: (–)

7 days

Takotsubo syndrome

3

0.45

Yes

Apical sparing

− 4.8

Without risk factors

30 days

Takotsubo syndrome

4

0.21

Yes

Apical sparing

− 6.1

Without risk factors

14 days

Takotsubo syndrome

5

0.62

No

CAG: (–)

HFpEF

6

0.64

Yes

Apical sparing

− 16.8

CTA: (–)

HFpEF

7

0.43

No

CTA: p-RCA 50% stenosis

12 days

Takotsubo syndrome

8

0.61

No

HFpEF, ischemic stroke

9

0.36

No

Without risk factors

11 days

Recurrent Takotsubo syndrome (3 times)

10

0.38

Yes

Segmental

− 21.2

CTA: (–)

11 days

Recurrent Takotsubo syndrome (2 times)

11

0.65

No

Without risk factors

HFpEF

12

0.59

Yes

Apical sparing

− 9.6

Without risk factors

7 days

Takotsubo syndrome

13

0.35

Yes

Apical sparing

− 13.6

CAG: (–)

15 days

Takotsubo syndrome

14

0.28

Yes

Global

CAG: (–)

Without recovery in 10 months

Catecholamine-induced cardiomyopathy

Case

Sex/age (years)*

Initial symptoms

Triggers

Labile blood pressure

Location of tumors

Plasma catecholamine (× ULN)

Troponin (pg/ml)

NT-proBNP (pg/ml)

ECG

E/MN

NE/NMN

1

50 s/male

Nausea, vomiting, dyspnea, palpitation

Physical activity

No

Left adrenal PHEO

5.9

2.5

1159

> 35,000

Sinus tachycardia, ST depression and T wave inversion in V4–6

2

30 s/male

Nausea, vomiting, dyspnea, palpitation, headache

Physical activity

No

Bilateral adrenal PHEO

15.8

4.2

1220

5976

ST depression and T inversion in V1–6, prolonged QTc interval

3

10 s/female

Dyspnea

Infection

No

Right adrenal PHEO

Normal

 > 12.1

19.3

2985

Sinus tachycardia

4

40 s/male

Dyspnea, palpitation, sweating

No

Yes

Right adrenal PHEO

4.0

Normal

2773

25,492

Sinus tachycardia, nonspecific T wave changes

5

40 s/female

dyspnea

No

No

Left adrenal PHEO

11.2

11.9

77.3

4740

T wave inversion in inferior leads

6

60 s/male

Dyspnea, palpitation, sweating

No

No

Left adrenal PHEO

2.6

57.5

84.3

7976

Diminished R wave in V2–3

7

50 s/male

Dyspnea, chest pain

Operation

No

Right adrenal PHEO

130.2

2250

Premature atrial complex

8

60 s/female

Nausea, vomiting, dyspnea, sweating

Defecation

Yes

Right adrenal PHEO

437.6

33,914

T wave inversion in inferior leads and V2–6

9

20 s/male

Nausea, dyspnea, palpitation, sweating

No

Yes

Left adrenal PHEO

8.4

11.4

663.6

26,508

Sinus tachycardia, second degree AVB

10

70 s/male

Nausea, vomiting, dyspnea

No

No

Right adrenal PHEO

9.4

2.9

2178

 > 35,000

Sinus tachycardia, low voltage in limb leads, ST depression in V3–6

11

30 s/female

Dyspnea, palpitation, sweating

Pregnancy

Yes

Retroperitoneal PGL

T wave inversion in inferior leads and V3–6

12

40 s/male

Nausea, vomiting, dyspnea, headache

No

Yes

Right adrenal PHEO

25.1

16.0

121.9

8946

T wave inversion in I, aVL, and V6

13

40 s/male

Nausea, vomiting, dyspnea, chest pain, headache

No

No

Left adrenal PHEO

10.4

7.6

954.2

12,913

ST depression in inferior leads and V4–6, ST elevation in aVR

14

50 s/male

Dyspnea

No

No

Pelvic PGL

Normal

 > 12.1

72.1

1208

Sinus tachycardia, LBBB

  1. AVB atrioventricular block, CAG coronary artery angiography, CTA coronary computed tomography angiography, E epinephrine, HFpEF heart failure with preserved ejection fraction, LBBB left bundle branch block, LVEF left ventricular ejection fraction, LS longitudinal strain, LV left ventricle, MN metanephrine, NE norepinephrine, NMN normetanephrine, PGL paraganglioma, PHEO pheochromocytoma, p-RCA proximal right coronary artery, ULN upper limit of normal. Other abbreviations as shown in Table 1
  2. *Ages expressed in decades to ensure patient anonymity in Tables 2 and 3