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Fig. 1 | BMC Cardiovascular Disorders

Fig. 1

From: Bone marrow-derived mesenchymal stem cells attenuate myocardial ischemia–reperfusion injury via upregulation of splenic regulatory T cells

Fig. 1

CD25+Foxp3+Tregs in the heart and spleen were increased by BM-MSCs administration in MIRI mice. Representative flow cytometry scatter plots confirm CD25 + Foxp3 + Tregs in spleen (a) and heart (b) from mice treated with IgG, IgG + BM-MSCs, PC61, and PC61 + BM-MSCs (n = 5 in each group) at indicated time. The group quantitation results of CD4 + CD25+Foxp3+ Tregs in the spleen (c) and the heart (d) are shown. Tissues were collected 72 h after surgically-induced MIRI. The bars shown in C and D represent the mean value ± standard deviation of each indicated group. BM-MSCs, bone marrow-derived mesenchymal stem cells; MIRI, myocardial ischemia–reperfusion injury; Treg, regulatory T cells. SEM ± SD, *p < 0.05, **p < 0.01 and ***p < 0.001

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