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Table 1 General characteristics of the study population according to tertiles of ln[homocysteine]

From: The association between homocysteine levels and cardiovascular disease risk among middle-aged and elderly adults in Taiwan

Variable

ln[homocysteine]

Total

Low

Middle

High

p value for trend

 

(< 2.42)

(2.42–2.66)

(≥ 2.67)

(n = 396)

(n = 132)

(n = 130)

(n = 134)

Age (year)

64.79 ± 8.76

64.17 ± 8.5

65.32 ± 9.34

64.87 ± 8.47

0.521

Gender (male), n(%)

164(41.4)

24(18.2)

52(40.0)

88(65.7)

 < 0.001

Fasting plasma glucose (mg/dL)

109.79 ± 35.65

102.89 ± 20.65

111.74 ± 41.87

114.68 ± 39.74

0.007

FRS (%)

2.61 ± 0.67

2.35 ± 0.62

2.60 ± 0.69

2.87 ± 0.60

 < 0.001

ln[homocysteine(umol/L)]

2.56 ± 0.32

2.23 ± 0.15

2.54 ± 0.07

2.90 ± 0.22

 < 0.001

TG (mg/dL)

141.07 ± 110.00

137.95 ± 105.33

141.65 ± 130.97

143.59 ± 91.41

0.677

LDL-C (mg/dl)

109.69 ± 33.99

113.27 ± 32.46

108.09 ± 35.97

107.71 ± 33.46

0.183

HDL-C (mg/dl)

53.56 ± 14.51

56.99 ± 13.87

54.42 ± 14.30

49.34 ± 14.41

 < 0.001

Uric Acid (mg/dL)

5.63 ± 1.52

5.13 ± 1.27

5.53 ± 1.35

6.23 ± 1.70

 < 0.001

ALT (U/L)

27.16 ± 22.82

26.06 ± 25.70

28.15 ± 21.44

27.28 ± 21.18

0.665

Creatinine (mg/dl)

0.87 ± 0.43

0.73 ± 0.14

0.80 ± 0.19

1.07 ± 0.66

 < 0.001

waist circumference (cm)

85.36 ± 10.83

81.01 ± 10.06

86.01 ± 10.55

89.00 ± 10.40

 < 0.001

SBP (mmHg)

137.30 ± 17.49

134.28 ± 16.60

137.29 ± 18.17

140.29 ± 17.29

0.005

DBP (mmHg)

85.19 ± 10.98

83.61 ± 10.62

84.04 ± 10.35

87.86 ± 11.49

0.001

BMI (kg/m2)

25.59 ± 3.84

24.53 ± 3.38

25.49 ± 3.54

26.74 ± 4.23

 < 0.001

Smoking, n(%)

50(12.6)

7(5.3)

14(10.8)

29(21.6)

 < 0.001

Alcohol drinking, n(%)

28(7.1)

8(6.1)

9(6.9)

11(8.2)

0.495

HTN, n(%)

201(50.8)

55(41.7)

63(48.5)

83(61.9)

0.001

DM, n(%)

133(33.6)

29(22.0)

49(37.7)

55(41.0)

0.001

Hyperlipidemia, n(%)

153(38.6)

49(37.1)

43(33.1)

61(45.5)

0.158

Vegetarian, n(%)

12(3.0)

4(3.0)

3(2.3)

5(3.7)

0.737

  1. Clinical characteristics are expressed as mean ± SD for continuous variables and n(%) for categorical variables. p value were derived from one-way analysis of variance (one-way ANOVA) for continuous variables and chi-square test for categorical variables
  2. FRS, Framingham cardiovascular risk score; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; ALT, alanine aminotransferase; SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; HTN, hypertension; DM, diabetes mellitus; CVD, cardiovascular disease