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Table 1 General characteristics of the study population according to tertiles of ln[homocysteine]

From: The association between homocysteine levels and cardiovascular disease risk among middle-aged and elderly adults in Taiwan

Variable ln[homocysteine]
Total Low Middle High p value for trend
  (< 2.42) (2.42–2.66) (≥ 2.67)
(n = 396) (n = 132) (n = 130) (n = 134)
Age (year) 64.79 ± 8.76 64.17 ± 8.5 65.32 ± 9.34 64.87 ± 8.47 0.521
Gender (male), n(%) 164(41.4) 24(18.2) 52(40.0) 88(65.7)  < 0.001
Fasting plasma glucose (mg/dL) 109.79 ± 35.65 102.89 ± 20.65 111.74 ± 41.87 114.68 ± 39.74 0.007
FRS (%) 2.61 ± 0.67 2.35 ± 0.62 2.60 ± 0.69 2.87 ± 0.60  < 0.001
ln[homocysteine(umol/L)] 2.56 ± 0.32 2.23 ± 0.15 2.54 ± 0.07 2.90 ± 0.22  < 0.001
TG (mg/dL) 141.07 ± 110.00 137.95 ± 105.33 141.65 ± 130.97 143.59 ± 91.41 0.677
LDL-C (mg/dl) 109.69 ± 33.99 113.27 ± 32.46 108.09 ± 35.97 107.71 ± 33.46 0.183
HDL-C (mg/dl) 53.56 ± 14.51 56.99 ± 13.87 54.42 ± 14.30 49.34 ± 14.41  < 0.001
Uric Acid (mg/dL) 5.63 ± 1.52 5.13 ± 1.27 5.53 ± 1.35 6.23 ± 1.70  < 0.001
ALT (U/L) 27.16 ± 22.82 26.06 ± 25.70 28.15 ± 21.44 27.28 ± 21.18 0.665
Creatinine (mg/dl) 0.87 ± 0.43 0.73 ± 0.14 0.80 ± 0.19 1.07 ± 0.66  < 0.001
waist circumference (cm) 85.36 ± 10.83 81.01 ± 10.06 86.01 ± 10.55 89.00 ± 10.40  < 0.001
SBP (mmHg) 137.30 ± 17.49 134.28 ± 16.60 137.29 ± 18.17 140.29 ± 17.29 0.005
DBP (mmHg) 85.19 ± 10.98 83.61 ± 10.62 84.04 ± 10.35 87.86 ± 11.49 0.001
BMI (kg/m2) 25.59 ± 3.84 24.53 ± 3.38 25.49 ± 3.54 26.74 ± 4.23  < 0.001
Smoking, n(%) 50(12.6) 7(5.3) 14(10.8) 29(21.6)  < 0.001
Alcohol drinking, n(%) 28(7.1) 8(6.1) 9(6.9) 11(8.2) 0.495
HTN, n(%) 201(50.8) 55(41.7) 63(48.5) 83(61.9) 0.001
DM, n(%) 133(33.6) 29(22.0) 49(37.7) 55(41.0) 0.001
Hyperlipidemia, n(%) 153(38.6) 49(37.1) 43(33.1) 61(45.5) 0.158
Vegetarian, n(%) 12(3.0) 4(3.0) 3(2.3) 5(3.7) 0.737
  1. Clinical characteristics are expressed as mean ± SD for continuous variables and n(%) for categorical variables. p value were derived from one-way analysis of variance (one-way ANOVA) for continuous variables and chi-square test for categorical variables
  2. FRS, Framingham cardiovascular risk score; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; ALT, alanine aminotransferase; SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; HTN, hypertension; DM, diabetes mellitus; CVD, cardiovascular disease