Inhaled nitric oxide preserves ventricular function during resuscitation using a percutaneous mechanical circulatory support device in a porcine cardiac arrest model: an echocardiographic myocardial work analysis

Nix, Christoph; Zayat, Rashad; Ebeling, Andreas; Goetzenich, Andreas; Chandrasekaran, Uma; Rossaint, Rolf; Hatam, Nima; Derwall, Matthias

doi:10.1186/s12872-021-01992-w

Table 2 Arterial blood gas analysis before, during and after resuscitation

From: Inhaled nitric oxide preserves ventricular function during resuscitation using a percutaneous mechanical circulatory support device in a porcine cardiac arrest model: an echocardiographic myocardial work analysis

	0 ppm	20 ppm	total	p
Baseline
Lactate mmol/L	1.3 ± 0.4	1.4 ± 0.5	1.3 ± 0.4	1.000
Hemoglobin g/dL	9.2 ± 0.8	9.3 ± 0.6	9.2 ± 0.7	0.834
Glucose mg/dL	132.8 ± 24.6	117.4 ± 9.7	125.1 ± 19.4	0.465
pH	7.48 ± 0.02	7.46 ± 0.01	7.47 ± 0.02	0.251
HCO₃ mmoL	30.1 ± 0.6	30.0 ± 1.1	30.1 ± 0.8	0.751
BE mmoL	6.1 ± 0.8	6.1 ± 1.1	6.1 ± 0.9	0.600
pO₂ mmHg	132.8 ± 25.4	149.2 ± 4.4	141.0 ± 19.2	0.251
pCO₂ mmHg	43.3 ± 2.4	39.8 ± 2.4	41.5 ± 2.9	0.057
iCPR
Lactate mmol/L	7.2 ± 0.6	7.0 ± 0.6	7.1 ± 0.6	0.402
Hemoglobin g/dL	10.7 ± 1.5	10.1 ± 0.7	10.4 ± 1.1	0.465
Glucose mg/dL	241.2 ± 63.2	266.0 ± 17.6	253.6 ± 45.6	0.754
pH	7.26 ± 0.03	7.29 ± 0.07	7.27 ± 0.05	0.347
HCO₃ mmoL	20.7 ± 2.1	21.7 ± 0.6	21.2 ± 1.5	0.602
BE mmoL	− 4.1 ± 2.4	− 3.6 ± 1.6	− 3.8 ± 1.9	0.917
pO₂ mmHg	396.4 ± 115.7	480.6 ± 25.9	438.5 ± 90.7	0.117
pCO₂ mmHg	47.3 ± 8.3	50.4 ± 4.0	48.8 ± 6.3	0.465
30 min post ROSC
Lactate mmol/L	7.1 ± 0.2	6.5 ± 1.4	6.8 ± 1.0	0.116
Hemoglobin g/dL	9.7 ± 1.3	9.3 ± 0.3	9.5 ± 0.9	0.600
Glucose mg/dL	225.4 ± 57.3	235.8 ± 20.2	230.6 ± 40.9	0.602
pH	7.39 ± 0.07	7.35 ± 0.1	7.37 ± 0.07	0.142
HCO₃ mmoL	22.5 ± 1.9	22.7 ± 2.3	22.6 ± 2.0	0.754
BE mmoL	− 2.5 ± 1.7	− 1.6 ± 2.7	− 2.1 ± 2.2	0.463
pO₂ mmHg	292.4 ± 167.1	496.6 ± 50.7	394.5 ± 158.5	0.028
pCO₂ mmHg	39.4 ± 9.3	41.8 ± 2.5	40.6 ± 6.5	0.602
3 h post ROSC
Lactate mmol/L	1.4 ± 0.5	1.5 ± 0.6	1.5 ± 0.5	0.530
Hemoglobin g/dL	9.0 ± 0.8	9.0 ± 0.4	9.0 ± 0.6	0.917
Glucose mg/dL	161.0 ± 51.1	163.4 ± 37.4	162.2 ± 42.3	0.602
pH	7.53 ± 0.05	7.51 ± 0.05	7.52 ± 0.05	0.465
HCO₃ mmoL	29.1 ± 1.0	28.7 ± 1.2	28.9 ± 1.1	0.402
BE mmoL	4.9 ± 1.2	4.8 ± 1.4	4.8 ± 1.2	1.000
pO₂ mmHg	131.7 ± 31.1	143.0 ± 19.2	137.4 ± 25.1	0.402
pCO₂ mmHg	34.4 ± 5.6	33.3 ± 5.6	33.9 ± 5.3	0.917
5 h post ROSC
Lactate mmol/L	1.0 ± 0.2	0.8 ± 0.2	0.9 ± 0.2	0.139
Hemoglobin g/dL	9.0 ± 0.8	9.4 ± 0.9	9.2 ± 0.8	0.401
Glucose mg/dL	140.6 ± 22.1	124.4 ± 24.4	132.5 ± 23.6	0.249
pH	7.49 ± 0.02	7.42 ± 0.03	7.45 ± 0.04	0.050
HCO₃ mmoL	30.7 ± 1.7	29.3 ± 1.3	30.0 ± 1.6	0.175
BE mmoL	7.2 ± 1.7	6.0 ± 1.6	6.6 ± 1.7	0.251
pO₂ mmHg	102.4 ± 15.4	141.4 ± 9.4	121.9 ± 23.9	0.010
pCO₂ mmHg	46.1 ± 1.9	38.7 ± 2.7	42.4 ± 4.4	0.007

BE: Base excess mmol/L; HCO3⁻: Hydrogen carbonate mmol/L; pH: Power of Hydrogen; pO₂: arterial partial pressure of oxygen mm Hg; pCO₂: arterial partial pressure of carbon dioxide mmHg

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