Parameter | 6 Month | 1 Year | 2 Year | 3 Year | ||||
---|---|---|---|---|---|---|---|---|
BAT + GDT | GDT Alone | BAT + GDT | GDT Alone | BAT + GDT | GDT Alone | BAT + GDT | GDT Alone | |
Heart failure medications (a, b) | ||||||||
ACE/ARB (c) | 0.97 | 1.07 | 1.95 | 2.13 | 3.90 | 4.44 | 5.85 | 6.84 |
Beta blocker | 1.83 | 1.89 | 3.67 | 3.79 | 7.34 | 7.89 | 11.01 | 12.15 |
Digitalis | 0.22 | 0.25 | 0.43 | 0.50 | 0.86 | 1.04 | 1.30 | 1.60 |
Diuretics | 2.71 | 2.78 | 5.42 | 5.57 | 10.83 | 11.59 | 16.25 | 17.86 |
ARNI (d) | 0.60 | 0.73 | 1.21 | 1.46 | 1.98 | 3.24 | 2.60 | 5.18 |
Ivabradine | 0.07 | 0.07 | 0.13 | 0.14 | 0.26 | 0.30 | 0.39 | 0.46 |
MRA (e) | 0.62 | 0.63 | 1.24 | 1.26 | 2.47 | 2.63 | 3.71 | 4.05 |
Other HF meds | 1.05 | 1.31 | 2.09 | 2.61 | 4.18 | 5.44 | 6.27 | 8.38 |
Cardiovascular Hospitalization (non-HF) Rate, Relative Reduction = 25% (f) | 0.08 | 0.10 | 0.15 | 0.20 | 0.3 | 0.40 | 0.45 | 0.60 |
Heart failure hospitalizations, relative reduction = 25% (f) | 0.13 | 0.18 | 0.26 | 0.35 | 0.53 | 0.70 | 0.79 | 1.05 |
LVAD (g) | 0.00% | 1.64% | 0.50% | 3.25% | 0.50% | 6.40% | 0.50% | 9.44% |
Heart transplant | 0.00% | 0.50% | 0.50% | 1.00% | 0.50% | 1.99% | 0.50% | 2.97% |
BAT-specific serious adverse events | ||||||||
Infections | 2.61% | |||||||
Other (h) | 0.87% |