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Table 4 Addictive interaction of important modifiers on the association between alanine aminotransferase levels and hypertension

From: The association between serum alanine aminotransferase and hypertension: A national based cross-sectional analysis among over 21 million Chinese adults

Variables n (%) Crude OR (95% CI) Multi-adjusted OR (95% CI) RERI AP[AB] S
ALT & BMI*     1.393 0.322 1.720
 0–40 & < 24 13,775,858 (65.28) 1 1    
 0–40 & ≥ 24 4,831,049 (22.89) 3.12 (3.10,3.13) 2.47 (2.46,2.49)    
  > 40 & < 24 1,165,030 (5.52) 1.71 (1.69,1.73) 1.46 (1.45,1.47)    
  > 40 & ≥ 24 1,294,200 (6.13) 5.87 (5.83,5.91) 4.23 (4.30,4.36)    
ALT & Drinking     0.214 0.093 0.377
 0–40 & No 16,181,008 (76.67) 1 1    
 0–40 & Yes 2,439,518 (11.56) 2.23 (2.22,2.25) 1.54 (1.53,1.55)    
  > 40 & No 1,867,240 (8.85) 2.37 (2.36,2.39) 1.55 (1.54,1.56)    
  > 40 & Yes 593,887 (2.81) 4.57 (4.53,4.60) 2.31 (2.29,2.33)    
ALT & Smoking     0.014 0.078 1.195
 0–40 & No 16,398,611 (77.70) 1 1    
 0–40 & Yes 2,225,434 (10.55) 1.90 (1.89,1.92) 1.27 (1.26,1.28)    
  > 40 & No 1,870,788 (8.86) 2.45 (2.44,2.47) 1.57 (1.56,1.58)    
  > 40 & Yes 590,777 (2.80) 3.73 (3.69,3.76) 1.86 (1.84,1.88)    
ALT & HBsAg††     -0.362 -0.297 1.017
 0–40 & − 17,712,079 (83.93) 1 1    
 0–40 & +  914,931 (4.34) 1.07 (1.06,1.08) 1.00 (0.98,1.01)    
  > 40 & − 2,169,086 (10.28) 2.59 (2.58,2.61) 1.58 (1.58,1.59)    
  > 40 & +  293,136 (1.39) 1.80 (1.77,1.83) 1.22 (1.20,1.24)    
  1. ALT: alanine aminotransferase; OR: odds ratio; BMI: body mass index; HBsAg: hepatitis B surface antigen; RERI: the relative excess risk due to interaction; AP[AB]: the proportion of disease among those with both exposures that is attributable to their interaction; S: the synergy index
  2. n(%): n, number of participants; %, proportion of participants
  3. *Adjusted for age, sex, ethnicity, area, education, average salt consumption, history of diabetes, overall stress and hepatitis B surface antigen status
  4. Adjusted for age, sex, ethnicity, area, education, body mass index, average salt consumption, history of diabetes, overall stress and hepatitis B surface antigen status
  5. ††Adjusted for age, sex, ethnicity, area, education, body mass index, average salt consumption, history of diabetes and overall stress