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Table 4 Addictive interaction of important modifiers on the association between alanine aminotransferase levels and hypertension

From: The association between serum alanine aminotransferase and hypertension: A national based cross-sectional analysis among over 21 million Chinese adults

Variables

n (%)

Crude OR (95% CI)

Multi-adjusted OR (95% CI)

RERI

AP[AB]

S

ALT & BMI*

   

1.393

0.322

1.720

 0–40 & < 24

13,775,858 (65.28)

1

1

   

 0–40 & ≥ 24

4,831,049 (22.89)

3.12 (3.10,3.13)

2.47 (2.46,2.49)

   

  > 40 & < 24

1,165,030 (5.52)

1.71 (1.69,1.73)

1.46 (1.45,1.47)

   

  > 40 & ≥ 24

1,294,200 (6.13)

5.87 (5.83,5.91)

4.23 (4.30,4.36)

   

ALT & Drinking†

   

0.214

0.093

0.377

 0–40 & No

16,181,008 (76.67)

1

1

   

 0–40 & Yes

2,439,518 (11.56)

2.23 (2.22,2.25)

1.54 (1.53,1.55)

   

  > 40 & No

1,867,240 (8.85)

2.37 (2.36,2.39)

1.55 (1.54,1.56)

   

  > 40 & Yes

593,887 (2.81)

4.57 (4.53,4.60)

2.31 (2.29,2.33)

   

ALT & Smoking†

   

0.014

0.078

1.195

 0–40 & No

16,398,611 (77.70)

1

1

   

 0–40 & Yes

2,225,434 (10.55)

1.90 (1.89,1.92)

1.27 (1.26,1.28)

   

  > 40 & No

1,870,788 (8.86)

2.45 (2.44,2.47)

1.57 (1.56,1.58)

   

  > 40 & Yes

590,777 (2.80)

3.73 (3.69,3.76)

1.86 (1.84,1.88)

   

ALT & HBsAg††

   

-0.362

-0.297

1.017

 0–40 & −

17,712,079 (83.93)

1

1

   

 0–40 & + 

914,931 (4.34)

1.07 (1.06,1.08)

1.00 (0.98,1.01)

   

  > 40 & −

2,169,086 (10.28)

2.59 (2.58,2.61)

1.58 (1.58,1.59)

   

  > 40 & + 

293,136 (1.39)

1.80 (1.77,1.83)

1.22 (1.20,1.24)

   
  1. ALT: alanine aminotransferase; OR: odds ratio; BMI: body mass index; HBsAg: hepatitis B surface antigen; RERI: the relative excess risk due to interaction; AP[AB]: the proportion of disease among those with both exposures that is attributable to their interaction; S: the synergy index
  2. n(%): n, number of participants; %, proportion of participants
  3. *Adjusted for age, sex, ethnicity, area, education, average salt consumption, history of diabetes, overall stress and hepatitis B surface antigen status
  4. †Adjusted for age, sex, ethnicity, area, education, body mass index, average salt consumption, history of diabetes, overall stress and hepatitis B surface antigen status
  5. ††Adjusted for age, sex, ethnicity, area, education, body mass index, average salt consumption, history of diabetes and overall stress