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Table 3 Associations between alanine aminotransferase levels and systolic or diastolic blood pressures

From: The association between serum alanine aminotransferase and hypertension: A national based cross-sectional analysis among over 21 million Chinese adults

ALT Levels (U/L) Total Hypertensive Normotensive
  LS-Means* S.E* β P value LS-Means* S.E* β P value LS-Means* S.E* β P value
SBP             
ALT, continuous 113.98 0.00 0.02  < 0.001 137.57 0.02 0.02  < 0.001 112.95 0.00 0.01  < 0.001
Group I             
0–40 113.50 0.00 136.73 0.02 112.61 0.00
 > 40 117.66 0.01 1.19  < 0.001 140.30 0.03 1.31  < 0.001 115.63 0.01 0.57  < 0.001
Group II             
0–20 112.57 0.00 135.95 0.03 111.83 0.00
20.01–40 114.75 0.00 0.27  < 0.001 137.37 0.03 -0.01 0.905 113.68 0.00 0.16  < 0.001
40.01–60 117.27 0.01 1.22  < 0.001 139.72 0.05 1.1  < 0.001 115.41 0.01 0.63  < 0.001
60.0–80 117.91 0.02 1.39  < 0.001 140.57 0.07 1.47  < 0.001 115.79 0.01 0.66  < 0.001
 > 80.01 118.45 0.02 1.59  < 0.001 141.30 0.07 1.64  < 0.001 116.09 0.01 0.71  < 0.001
Pfor trend††  < 0.001      < 0.001      < 0.001    
DBP             
ALT, continuous 73.88 0.00 0.01  < 0.001 93.41 0.01 0.01  < 0.001 73.02 0.00 0.01  < 0.001
Group I             
0–40 73.57 0.00 93.27 0.01 72.82 0.00
 > 40 76.20 0.01 0.88  < 0.001 93.86 0.03 0.37  < 0.001 74.60 0.01 0.41  < 0.001
Group II             
0–20 72.92 0.00 93.11 0.02 72.29 0.00
20.01–40 74.45 0.00 0.39  < 0.001 93.41 0.02 0.32  < 0.001 73.55 0.00 0.28  < 0.001
40.01–60 75.93 0.01 0.98  < 0.001 93.64 0.03 0.42  < 0.001 74.45 0.01 0.52  < 0.001
60.0–80 76.38 0.01 1.15  < 0.001 94.05 0.05 0.75  < 0.001 74.71 0.01 0.57  < 0.001
 > 80 76.74 0.01 1.31  < 0.001 94.18 0.05 0.77  < 0.001 74.89 0.01 0.63  < 0.001
Pfor trend††  < 0.001      < 0.001      < 0.001    
  1. SBP: systolic blood pressure; DBP: diastolic blood pressure; ALT: alanine aminotransferase; LS-Means: Least-squares means; S.E: standard error of the LS-Means
  2. *Adjusted for age
  3. Adjusted for age, sex, ethnicity, area, education, body mass index, average salt consumption, history of diabetes, overall stress and hepatitis B surface antigen status
  4. ††P for trend were calculated by setting categorized ALT levels as a continuous variable