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Table 4 C-statistics and category free net reclassification improvement (NRI) of predictive models for incident AF†

From: Supraventricular arrhythmia, N-terminal pro-brain natriuretic peptide and troponin T concentration in relation to incidence of atrial fibrillation: a prospective cohort study

N = 364 C-statistic (95%CI) P for difference‡ NRI
CHARGE-AF score 0.720 (0.669, 0.771) Reference Reference
Frequent SVEs 0.778 (0.703, 0.854) 0.075  − 0.222 (− 0.372, 0.059)
Elevated NT-proBNP 0.726 (0.635, 0.817) 0.448  − 0.277 (− 0.427, − 0.001)
Elevated TnT 0.705 (0.610, 0.799) 0.376  − 0.258 (− 0.425, − 0.098)
Frequent SVEs + elevated NT-proBNP 0.768 (0.704, 0.832) 0.084  − 0.126 (− 0.334, 0.158)
CHARGE-AF score + frequent SVEs 0.743 (0.694, 0.793) 0.020 0.311 (0.182, 0.440)
CHARGE-AF score + elevated NT-proBNP 0.734 (0.685, 0.783) 0.110 0.288 (− 0.028, 0.385)
CHARGE-AF score + elevated TnT 0.717 (0.664, 0.769) 0.392 0.201 (− 0.176, 0.362)
CHARGE-AF score + frequent SVEs + elevated NT-proBNP 0.751 (0.702, 0.799) 0.015 0.300 (0.166, 0.452)
  1. Frequent SVEs, elevated NT-proBNP and elevated TnT were defined as the top quartile, corresponding to > 129.18 SVEs/24 h, 32.80 pg/ml NT-proBNP and > 1.38 pg/ml TnT, respectively
  2. AF atrial fibrillation, SVEs supraventricular extrasystoles, NT-proBNP N terminal pro B type natriuretic peptide; TnT troponin T
  3. †Net reclassification improvement was calculated for a 15-year AF risk prediction
  4. ‡P for difference in C-statistics compared to the Reference group
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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