Supraventricular arrhythmia, N-terminal pro-brain natriuretic peptide and troponin T concentration in relation to incidence of atrial fibrillation: a prospective cohort study

Table 4 C-statistics and category free net reclassification improvement (NRI) of predictive models for incident AF^†

N = 364	C-statistic (95%CI)	P for difference^‡	NRI
CHARGE-AF score	0.720 (0.669, 0.771)	Reference	Reference
Frequent SVEs	0.778 (0.703, 0.854)	0.075	− 0.222 (− 0.372, 0.059)
Elevated NT-proBNP	0.726 (0.635, 0.817)	0.448	− 0.277 (− 0.427, − 0.001)
Elevated TnT	0.705 (0.610, 0.799)	0.376	− 0.258 (− 0.425, − 0.098)
Frequent SVEs + elevated NT-proBNP	0.768 (0.704, 0.832)	0.084	− 0.126 (− 0.334, 0.158)
CHARGE-AF score + frequent SVEs	0.743 (0.694, 0.793)	0.020	0.311 (0.182, 0.440)
CHARGE-AF score + elevated NT-proBNP	0.734 (0.685, 0.783)	0.110	0.288 (− 0.028, 0.385)
CHARGE-AF score + elevated TnT	0.717 (0.664, 0.769)	0.392	0.201 (− 0.176, 0.362)
CHARGE-AF score + frequent SVEs + elevated NT-proBNP	0.751 (0.702, 0.799)	0.015	0.300 (0.166, 0.452)

Frequent SVEs, elevated NT-proBNP and elevated TnT were defined as the top quartile, corresponding to > 129.18 SVEs/24 h, 32.80 pg/ml NT-proBNP and > 1.38 pg/ml TnT, respectively
AF atrial fibrillation, SVEs supraventricular extrasystoles, NT-proBNP N terminal pro B type natriuretic peptide; TnT troponin T
^†Net reclassification improvement was calculated for a 15-year AF risk prediction
^‡P for difference in C-statistics compared to the Reference group

ISSN: 1471-2261