Supraventricular arrhythmia, N-terminal pro-brain natriuretic peptide and troponin T concentration in relation to incidence of atrial fibrillation: a prospective cohort study

Table 3 Incidence of AF by occurrence of elevated TnT and frequent supraventricular arrhythmias

N = 373	Subjects	Incident AF cases	Incidence rate (per 1000 person-years)	Model 1 h (95%CI)	Model 2 h (95%CI)
TnT and SVEs
Non-elevated TnT, infrequent SVEs	225	37	10.00	Ref	Ref
Elevated TnT, infrequent SVEs	54	10	12.76	1.09 (0.54, 2.20)^†	0.96 (0.47, 1.97)^†
Non-elevated TnT, frequent SVEs	55	19	23.69	2.24 (1.28, 3.92)	2.30 (1.30, 4.09)
Elevated TnT, frequent SVEs	39	22	46.69	3.71 (2.11, 6.51)	3.07 (1.74, 5.41)
Interaction TnT *SVEs				P = 0.377	P = 0.501
TnT and SVTs
Non-elevated TnT, infrequent SVTs	221	33	9.18	Ref	Ref
Elevated TnT, infrequent SVTs	54	14	18.22	1.66 (0.88, 3.12)	1.43 (0.75, 2.74)
Non-elevated TnT, frequent SVTs	59	23	25.27	2.40 (1.40, 4.11)	2.29 (1.31, 4.02)
Elevated TnT, frequent SVTs	39	18	37.02	2.99 (1.65, 5.45)	2.58 (1.40, 4.76)
Interaction TnT *SVTs				P = 0.528	P = 0.599
TnT and SVA
Non-elevated TnT, non-elevated SVA	198	30	9.22	Ref	Ref
Elevated TnT, non-elevated SVA	50	10	13.79	1.27 (0.62, 2.62)^‡	1.07 (0.51, 2.24)^‡
Non-elevated TnT, elevated SVA	82	26	20.79	1.97 (1.16, 3.35)	1.91 (1.10, 3.33)
Elevated TnT, elevated SVA	43	22	41.55	3.35 (1.87, 5.99)	2.85 (1.58, 5.13)
Interaction TnT *SVA				P = 0.533	P = 0.493

Model 1: age, sex adjusted (n = 373)
Model 2: Model 1 + smoking status + anti-hypertension medications + systolic blood pressure + LDL + natural log of HOMA-IR + height + weight (n = 364)
Frequent SVEs, SVTs, and elevated TnT were defined as the top quartile, corresponding to > 129.18 SVEs/24 h, 3.06 SVTs/24 h and > 1.38 pg/ml TnT, respectively; elevated SVA was defined as frequent SVEs or SVTs
AF atrial fibrillation, TnT troponin T, SVEs supraventricular extrasystoles, SVTs supraventricular tachycardias, SVA supraventricular activity
^†P < 0.05 when compared to group with elevated TnT and frequent SVEs
^‡P < 0.05 when compared to group with elevated TnT and elevated SVA

ISSN: 1471-2261