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Table 2 Incidence of AF by occurrence of elevated NT-proBNP and frequent supraventricular arrhythmias

From: Supraventricular arrhythmia, N-terminal pro-brain natriuretic peptide and troponin T concentration in relation to incidence of atrial fibrillation: a prospective cohort study

N = 373 Subjects Incident AF cases Incidence rate (per 1000 person-years) Model 1 h (95%CI) Model 2 h (95%CI)
NT-proBNP and SVEs
 Non-elevated NT-proBNP, infrequent SVEs 220 35 9.49 Ref Ref
 Elevated NT-proBNP, infrequent SVEs 59 12 15.07 1.45 (0.75, 2.80)† 1.52 (0.76, 3.05)†
 Non-elevated NT-proBNP, frequent SVEs 60 22 25.30 2.48 (1.45, 4.26) 2.32 (1.33, 4.06)†
 Elevated NT-proBNP, frequent SVEs 34 19 47.05 4.19 (2.30, 7.65) 4.61 (2.45, 8.69)
Interaction NT-proBNP * SVEs     P = 0.740 P = 0.582
NT-proBNP and SVTs
 Non-elevated NT-proBNP, infrequent SVTs 214 31 8.68 Ref Ref
 Elevated NT-proBNP, infrequent SVTs 61 16 20.24 1.99 (1.08, 3.67) 2.03 (1.07, 3.87)‡
 Non-elevated NT-proBNP, frequent SVTs 66 26 26.08 2.52 (1.48, 4.29) 2.26 (1.30, 3.95)
 Elevated NT-proBNP, frequent SVTs 32 15 36.66 3.55 (1.88, 6.70) 4.46 (2.24, 8.88)
Interaction NT-proBNP *SVTs     P = 0.443 P = 0.945
NT-proBNP and SVA
 Non-elevated NT-proBNP, non-elevated SVA 195 28 8.54 Ref Ref
 Elevated NT-proBNP, non-elevated SVA 53 12 17.11 1.74 (0.88, 3.44)§ 1.76 (0.86, 3.62)§
 Non-elevated NT-proBNP, elevated SVA 85 29 22.63 2.23 (1.32, 3.79) 2.10 (1.21, 3.65)§
 Elevated NT-proBNP, elevated SVA 40 19 38.10 3.65 (1.98, 6.73) 4.33 (2.26, 8.31)
Interaction NT-proBNP *SVA     P = 0.894 P = 0.740
  1. Model 1: age, sex adjusted (n = 373)
  2. Model 2: Model 1 + smoking status + anti-hypertension medications + systolic blood pressure + LDL + log of HOMA-IR + height + weight (n = 364)
  3. Frequent SVEs, SVTs, and elevated NT-proBNP were defined as the top quartile, corresponding to > 129.18 SVEs/24 h, 3.06 SVTs/24 h and 32.80 pg/ml NT-proBNP, respectively; elevated SVA was defined as frequent SVEs or SVTs
  4. AF atrial fibrillation, NT-proBNP N terminal pro B type natriuretic peptide, SVEs supraventricular extrasystoles, SVTs supraventricular tachycardias, SVA supraventricular activity
  5. †P < 0.05 when compared to group with elevated NT-proBNP and frequent SVEs
  6. ‡P < 0.05 when compared to group with elevated NT-proBNP and frequent SVTs
  7. §P < 0.05 when compared to group with elevated NT-proBNP and elevated SVA
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BMC Cardiovascular Disorders

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