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Table 5 Univariate and multivariate analysis for factors significantly and independently associated with anticoagulant prescription

From: Characteristics and antithrombotic treatment patterns of patients with concomitant coronary artery disease and atrial fibrillation from Thailand’s COOL-AF registry

Factors Univariate analysis Multivariate analysis
OR (95% CI) p OR (95% CI) p
BMI > 25 kg/m2 1.23 (0.99–1.52) 0.065   
Paroxysmal AF versus permanent AF 0.68 (0.55–0.84)  < 0.001 0.74 (0.55–1.00) 0.048
CAD 0.59 (0.47–0.74)  < 0.001 2.49 (1.76–3.52)  < 0.001
Heart failure 0.72 (0.58–0.89) 0.003   
Ischemic stroke or TIA 2.54 (1.88–3.43)  < 0.001 1.85 (1.25–2.74) 0.002
PAD 0.54 (0.28–1.06) 0.072   
On renal replacement therapy 0.31 (0.16–0.61) 0.001   
Chronic liver disease 0.48 (0.23–1.02) 0.055   
Antiplatelet use 0.03 (0.03–0.04)  < 0.001 0.02 (0.01–0.03)  < 0.001
Rate and rhythm control medications     
 Beta-blocker 1.34 (1.08–1.66) 0.008 1.81 (1.32–2.46)  < 0.001
 Proton pump inhibitors 0.54 (0.43–0.67)  < 0.001   
 Statin 1.29 (1.04–1.59) 0.020 1.97 (1.43–2.72)  < 0.001
 ACEI 1.34 (1.04–1.72) 0.024   
 Diuretic 1.22 (0.98–1.52) 0.076   
  1. A p-value < 0.05 indicates statistical significance
  2. OR, odds ratio; CI, confidence interval; BMI, body mass index; AF, atrial fibrillation; CAD, coronary artery disease; TIA, transient ischemic attack; PAD, peripheral arterial disease; ACEI, angiotensin-converting enzyme inhibitor