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Table 2 Baseline characteristics of atrial fibrillation compared between those without and with coronary artery disease

From: Characteristics and antithrombotic treatment patterns of patients with concomitant coronary artery disease and atrial fibrillation from Thailand’s COOL-AF registry

Characteristics

CAD (n = 557)

No CAD (n = 2904)

p-value

Age (years)

70.0 ± 9.9

66.9 ± 11.5

 < 0.001

Age 65–74

210 (37.7%)

902 (31.1%)

0.002

Age ≥ 75

185 (33.2%)

813 (28.0%)

0.013

Male sex

371 (66.6%)

1,643 (56.6%)

 < 0.001

Body weight (kg)

66.3 ± 13.9

66.1 ± 14.9

0.763

BMI (kg/m2)

25.1 ± 4.3

25.2 ± 4.8

0.767

Type of AF

 Paroxysmal AF

188 (33.8%)

891 (30.7%)

0.152

 Persistent/permanent AF

353 (63.4%)

1,938 (66.7%)

0.125

 CHA2DS2VASc score

4.17 ± 1.53

2.78 ± 1.60

 < 0.001

 Non-gender CHA2DS2-VASc score

3.84 ± 1.41

2.34 ± 1.48

 < 0.001

 Non-gender CHA2DS2-VASc score 0–1

20 (3.6%)

877 (30.2%)

 

 Non-gender CHA2DS2-VASc score of 2 or more

537 (96.4%)

2,027 (69.8%)

 

 HAS-BLED score

2.01 ± 1.01

1.45 ± 0.98

 < 0.001

 Non-antiplatelet HAS-BLED score

1.43 ± 0.90

1.24 ± 0.96

 < 0.001

Comorbidities

   

History of heart failure

217 (39.0%)

706 (24.3%)

 < 0.001

NYHA class

  

0.288

 I

58 (26.7%)

239 (33.9%)

 

 II

125 (57.6%)

371 (52.5%)

 

 III

23 (10.6%)

56 (7.9%)

 

 IV

3 (1.4%)

9 (1.3%)

 

 LVEF (%)

54.4 ± 17.1

61.0 ± 14.0

 < 0.001

 Hypertension

416 (74.7%)

1,948 (67.1%)

 < 0.001

 Diabetes mellitus

205 (36.8%)

645 (22.2%)

 < 0.001

 History of TIA/stroke

81 (14.5%)

521 (17.9%)

0.053

 PAD

17 (3.1%)

28 (1.0%)

 < 0.001

 History of major bleeding

15 (22.7%)

57 (21.8%)

0.865

 Intracranial hemorrhage

1 (6.7%)

18 (31.6%)

0.096

 GI hemorrhage

11 (73.3%)

26 (45.6%)

0.056

Chronic kidney disease

 eGFR (mL/min)

48.5 ± 20.0

57.4 ± 21.2

 < 0.001

 GFR < 60 mL/min

333 (73.7%)

1,254 (59.0%)

 < 0.001

 On renal replacement therapy

17 (3.1%)

23 (0.8%)

 < 0.001

 Chronic liver disease

13 (2.3%)

68 (2.3%)

0.991

 Labile INR

171 (30.7%)

724 (24.9%)

0.004

 CIED

82 (14.7%)

263 (9.1%)

 < 0.001

 Pacemaker

51 (62.2%)

222 (84.4%)

 < 0.001

 ICD/CRT-D

31 (37.8%)

40 (15.2%)

 < 0.001

 CRT-P/CRT-D

9 (11.0%)

8 (3.0%)

0.007

  1. Data presented as mean ± standard deviation or number and percentage
  2. A p-value < 0.05 indicates statistical significance
  3. CAD, coronary artery disease; BMI, body mass index; AF, atrial fibrillation; HAS-BLED, Hypertension, Abnormal liver/renal function, Stroke history, Bleeding history or predisposition, Labile INR, Elderly, Drug/alcohol usage; NYHA, New York Heart Association; LVEF, left ventricular ejection fraction; TIA, transient ischemic attack; PAD, peripheral arterial disease; GI, gastrointestinal; eGFR, estimated glomerular filtration rate; INR, international normalized ratio; CIED, cardiovascular implantable electronic devices; ICD, implantable cardioverter defibrillator; CRT-D, cardiac resynchronization therapy defibrillator; CRT-P, cardiac resynchronization therapy pacemaker
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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