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Table 2 Baseline characteristics of atrial fibrillation compared between those without and with coronary artery disease

From: Characteristics and antithrombotic treatment patterns of patients with concomitant coronary artery disease and atrial fibrillation from Thailand’s COOL-AF registry

Characteristics CAD (n = 557) No CAD (n = 2904) p-value
Age (years) 70.0 ± 9.9 66.9 ± 11.5  < 0.001
Age 65–74 210 (37.7%) 902 (31.1%) 0.002
Age ≥ 75 185 (33.2%) 813 (28.0%) 0.013
Male sex 371 (66.6%) 1,643 (56.6%)  < 0.001
Body weight (kg) 66.3 ± 13.9 66.1 ± 14.9 0.763
BMI (kg/m2) 25.1 ± 4.3 25.2 ± 4.8 0.767
Type of AF
 Paroxysmal AF 188 (33.8%) 891 (30.7%) 0.152
 Persistent/permanent AF 353 (63.4%) 1,938 (66.7%) 0.125
 CHA2DS2VASc score 4.17 ± 1.53 2.78 ± 1.60  < 0.001
 Non-gender CHA2DS2-VASc score 3.84 ± 1.41 2.34 ± 1.48  < 0.001
 Non-gender CHA2DS2-VASc score 0–1 20 (3.6%) 877 (30.2%)  
 Non-gender CHA2DS2-VASc score of 2 or more 537 (96.4%) 2,027 (69.8%)  
 HAS-BLED score 2.01 ± 1.01 1.45 ± 0.98  < 0.001
 Non-antiplatelet HAS-BLED score 1.43 ± 0.90 1.24 ± 0.96  < 0.001
Comorbidities    
History of heart failure 217 (39.0%) 706 (24.3%)  < 0.001
NYHA class    0.288
 I 58 (26.7%) 239 (33.9%)  
 II 125 (57.6%) 371 (52.5%)  
 III 23 (10.6%) 56 (7.9%)  
 IV 3 (1.4%) 9 (1.3%)  
 LVEF (%) 54.4 ± 17.1 61.0 ± 14.0  < 0.001
 Hypertension 416 (74.7%) 1,948 (67.1%)  < 0.001
 Diabetes mellitus 205 (36.8%) 645 (22.2%)  < 0.001
 History of TIA/stroke 81 (14.5%) 521 (17.9%) 0.053
 PAD 17 (3.1%) 28 (1.0%)  < 0.001
 History of major bleeding 15 (22.7%) 57 (21.8%) 0.865
 Intracranial hemorrhage 1 (6.7%) 18 (31.6%) 0.096
 GI hemorrhage 11 (73.3%) 26 (45.6%) 0.056
Chronic kidney disease
 eGFR (mL/min) 48.5 ± 20.0 57.4 ± 21.2  < 0.001
 GFR < 60 mL/min 333 (73.7%) 1,254 (59.0%)  < 0.001
 On renal replacement therapy 17 (3.1%) 23 (0.8%)  < 0.001
 Chronic liver disease 13 (2.3%) 68 (2.3%) 0.991
 Labile INR 171 (30.7%) 724 (24.9%) 0.004
 CIED 82 (14.7%) 263 (9.1%)  < 0.001
 Pacemaker 51 (62.2%) 222 (84.4%)  < 0.001
 ICD/CRT-D 31 (37.8%) 40 (15.2%)  < 0.001
 CRT-P/CRT-D 9 (11.0%) 8 (3.0%) 0.007
  1. Data presented as mean ± standard deviation or number and percentage
  2. A p-value < 0.05 indicates statistical significance
  3. CAD, coronary artery disease; BMI, body mass index; AF, atrial fibrillation; HAS-BLED, Hypertension, Abnormal liver/renal function, Stroke history, Bleeding history or predisposition, Labile INR, Elderly, Drug/alcohol usage; NYHA, New York Heart Association; LVEF, left ventricular ejection fraction; TIA, transient ischemic attack; PAD, peripheral arterial disease; GI, gastrointestinal; eGFR, estimated glomerular filtration rate; INR, international normalized ratio; CIED, cardiovascular implantable electronic devices; ICD, implantable cardioverter defibrillator; CRT-D, cardiac resynchronization therapy defibrillator; CRT-P, cardiac resynchronization therapy pacemaker