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Table 1 Baseline characteristics of the study cohort

From: Combined effect of menopause and cardiovascular risk factors on death and cardiovascular disease: a cohort study

  All (n = 2104) Menopause staging at baseline Age at menopause
Reproductive (n = 1252) Perimenopause (n = 309) Early postmenopause (n = 283) Late postmenopause (n = 260) P value < 45 years (n = 160) 45–49 years (n = 790) 50–51 years (n = 506) 52–53 years (n = 375) ≥ 54 years (n = 273) P value
Age at baseline (years old), mean ± SD 45.2 ± 7.8 39.9 ± 3.5 48.9 ± 4.4 53.0 ± 3.9 57.6 ± 4.4 < 0.001 47.0 ± 8.1 43.6 ± 7.1 46.2 ± 8.1 45.2 ± 7.8 46.7 ± 7.9 < 0.001
Body mass index (kg/m2), mean ± SD 23.9 ± 3.4 23.9 ± 3.5 24.2 ± 3.3 23.8 ± 3.2 23.6 ± 3.1 0.29 24.4 ± 3.5 23.9 ± 3.5 23.5 ± 3.3 24.0 ± 3.2 24.0 ± 3.4 0.02
Smoking, n (%) 18 (0.9) 7 (0.6) 6 (1.9) 2 (0.7) 3 (1.2) 0.11 0 (0.0) 7 (0.9) 8 (1.6) 1 (0.3) 2 (0.7) 0.19
Systolic blood pressure (mmHg), mean ± SD 119.2 ± 18.1 114.5 ± 15.2 123.0 ± 17.9 125.2 ± 18.9 130.9 ± 22.1 < 0.001 121.9 ± 18.6 118.1 ± 17.7 119.3 ± 19.0 119.3 ± 17.8 120.3 ± 17.6 0.12
Diastolic blood pressure (mmHg), mean ± SD 75.6 ± 10.5 73.6 ± 9.7 77.9 ± 11.1 78.4 ± 10.8 79.9 ± 11.1 < 0.001 77.2 ± 10.7 75.1 ± 10.5 75.6 ± 10.7 75.5 ± 10.3 76.4 ± 10.5 0.11
Hypertension, n (%) 347 (16.5) 119 (9.5) 71 (23.1) 74 (26.1) 83 (31.9) < 0.001 31 (19.4) 124 (15.7) 82 (16.2) 58 (15.5) 52 (19.0) 0.57
Total cholesterol (mmol/L), mean ± SD 4.67 ± 0.88 4.40 ± 0.77 4.84 ± 0.86 5.11 ± 0.82 5.29 ± 0.86 < 0.001 4.93 ± 0.83 4.61 ± 0.86 4.72 ± 0.89 4.66 ± 0.91 4.63 ± 0.86 0.001
Triglyceride (mmol/L), mean ± SD 1.09 ± 0.74 1.00 ± 0.64 1.14 ± 0.79 1.23 ± 0.98 1.36 ± 0.73 < 0.001 1.23 ± 0.74 1.00 ± 0.54 1.10 ± 0.87 1.15 ± 0.73 1.17 ± 0.93 < 0.001
High density lipoprotein cholesterol (mmol/L), mean ± SD 1.52 ± 0.36 1.51 ± 0.36 1.55 ± 0.36 1.58 ± 0.37 1.47 ± 0.34 0.001 1.52 ± 0.36 1.55 ± 0.36 1.51 ± 0.35 1.51 ± 0.35 1.47 ± 0.35 0.04
Low density lipoprotein cholesterol (mmol/L), mean ± SD 2.93 ± 0.83 2.69 ± 0.74 3.07 ± 0.82 3.29 ± 0.81 3.55 ± 0.82 < 0.001 3.16 ± 0.81 2.86 ± 0.81 2.99 ± 0.85 2.92 ± 0.88 2.92 ± 0.79 0.001
Fasting blood glucose (mmol/L), mean ± SD 5.28 ± 0.91 5.20 ± 0.89 5.33 ± 0.82 5.34 ± 0.78 5.58 ± 1.16 < 0.001 5.35 ± 0.96 5.28 ± 1.02 5.28 ± 0.76 5.28 ± 0.90 5.28 ± 0.84 0.94
Type 2 diabetes, n (%) 50 (2.4) 24 (1.9) 8 (2.6) 8 (2.8) 10 (3.9) 0.27 2 (1.3) 25 (3.2) 10 (2.0) 5 (1.3) 8 (2.9) 0.25
  1. SD standard deviation
  2. P values were calculated for continuous variables using analysis of variance or for categorical variables using the χ2 test