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Table 3 Values of resuscitation, return of spontaneous circulation and survival

From: The effect of high-dose intramuscular epinephrine on the recovery of spontaneous circulation in an asphyxia‐induced cardiac arrest rat model

Values

IV epinephrine group

IM epinephrine group

Control saline group

Sham group

P-value

Induction time of cardiac arrest (time to MAP < 20 mm Hg) (s)

172.0 ± 6.6

168.15 ± 3.7

168.9 ± 4.7

 

0.866

Resuscitation time (resuscitation to ROSC) (s)

61.7 ± 2.3

582.8 ± 52.5

441.0 ± 58.0

 

< 0.001*

Lactate after ROSC (mmol  L− 1)

8.0 ± 0.4

6.3 ± 0.4

7.0 ± 0.0

 

0.102

Latate at 60 min 

after ROSC (mmol L− 1)

1.0 ± 0.1

0.9 ± 0.1

0.8 ± 0.0

0.9 ± 0.0

0.475

MAP after ROSC (mm Hg)

61.0 ± 1.8

48.1 ± 1.7

49.0 ± 0.0

 

0.001†

HR after ROSC

341.2 ± 2.8

280.3 ± 8.0

289.0 ± 0.0

 

< 0.001†

MAP at 60 min after ROSC (mm Hg)

63.6 ± 1.9

63.6 ± 1.9

53.0 ± 0.0

86.8 ± 0.6

0.255

HR at 60 min after ROSC

206.5 ± 4.8

214.6 ± 9.1

206 ± 0.0

294.7 ± 1.4

0.853

Rates of ROSC

13/13 (100%)

8/13 (61.5%)

2/13 (15.4%)

 

< 0.001

Survival rates for 60 min after ROSC

11/13 (84.6%)

8/13 (61.5%)

1/13 (7.7%)

6/6 (100%)

< 0.001

  1. IV intravenous, IM intramuscular, MAP mean arterial pressure, HR heart rate, 95% CI 95% confidence interval, ROSC return of spontaneous circulation; Mean ± Standard Error; P < 0.001 compared IV to IM epinephrine, P < 0.019 compared IV epinephrine to Control group, †P < 0.001 compared IV to IM epinephrine group (post hoc analysis)