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Table 3 Values of resuscitation, return of spontaneous circulation and survival

From: The effect of high-dose intramuscular epinephrine on the recovery of spontaneous circulation in an asphyxia‐induced cardiac arrest rat model

Values IV epinephrine group IM epinephrine group Control saline group Sham group P-value
Induction time of cardiac arrest (time to MAP < 20 mm Hg) (s) 172.0 ± 6.6 168.15 ± 3.7 168.9 ± 4.7   0.866
Resuscitation time (resuscitation to ROSC) (s) 61.7 ± 2.3 582.8 ± 52.5 441.0 ± 58.0   < 0.001*
Lactate after ROSC (mmol  L− 1) 8.0 ± 0.4 6.3 ± 0.4 7.0 ± 0.0   0.102
Latate at 60 min 
after ROSC (mmol L− 1)
1.0 ± 0.1 0.9 ± 0.1 0.8 ± 0.0 0.9 ± 0.0 0.475
MAP after ROSC (mm Hg) 61.0 ± 1.8 48.1 ± 1.7 49.0 ± 0.0   0.001†
HR after ROSC 341.2 ± 2.8 280.3 ± 8.0 289.0 ± 0.0   < 0.001†
MAP at 60 min after ROSC (mm Hg) 63.6 ± 1.9 63.6 ± 1.9 53.0 ± 0.0 86.8 ± 0.6 0.255
HR at 60 min after ROSC 206.5 ± 4.8 214.6 ± 9.1 206 ± 0.0 294.7 ± 1.4 0.853
Rates of ROSC 13/13 (100%) 8/13 (61.5%) 2/13 (15.4%)   < 0.001
Survival rates for 60 min after ROSC 11/13 (84.6%) 8/13 (61.5%) 1/13 (7.7%) 6/6 (100%) < 0.001
  1. IV intravenous, IM intramuscular, MAP mean arterial pressure, HR heart rate, 95% CI 95% confidence interval, ROSC return of spontaneous circulation; Mean ± Standard Error; P < 0.001 compared IV to IM epinephrine, P < 0.019 compared IV epinephrine to Control group, †P < 0.001 compared IV to IM epinephrine group (post hoc analysis)