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Table 4 Multivariable linear regression. PWV as a function of the proteins with factor loadings (> 0.4) on principal component 3. Established risk factors of atherosclerosis are included in the multivariable model

From: IGFBP-1 and IGFBP-2 are associated with a decreased pulse-wave velocity in young, healthy adults

 

R2

β (95% CI)

p value

TFF3 + Model 1

0.063

0.036 (− 0.019; 0.90)

0.20

GDF-15 + Model 1

0.062

0.11 (− 0.062;− 0.029)

0.20

RARRES2 + Model 1

0.065

0.23 (0.0081;0.45)

0.058

IGFBP-2 + Model 1

0.069

− 0.18 (− 0.29;− 0.065)

0.0022*

CD166 + Model 1

0.062

0.18 (− 0.087;0.44)

0.19

IGFBP-1 + Model 1

0.068

− 0.10 (− 0.18;− 0.017)

0.018*

OPG + Model 1

0.061

0.091 (− 0.12;0.30)

0.39

MMP-3 + Model 1

0.060

− 0.0021 (− 0.12;0.12)

0.98

AZU1 + Model 1

0.061

− 0.029 (− 0.17;11)

0.68

ST2 + Model 1

0.062

− 0.014 (− 0.13;0.10)

0.81

CCL15 + Model 1

 

0.12 (− 0.0069;0.25)

0.062

  1. Model 1 includes age, sex, body fat%, Apolipoprotein B/Apolipoprotein A-1 ratio, Homeostatic model assessment insulin resistance (HOMA-IR) and C-reactive protein (CRP). TFF3 = Trefoil factor 3. GDF-15 = Growth/differentiation factor 15. RARRES2 = Retinoic acid receptor responder protein 2. IGFBP-2 = Insulin-like growth factor-binding protein 2. CD166 = CD166 antigen. IGFBP-1 = Insulin-like growth factor-binding protein 1. OPG = Osteoprotegrin. MMP3 = Matrix metalloproteinase-3. AZU1 = Azurocidin. ST2 = ST2 protein. CCL15 = C–C motif chemokine 15. * indicates a p value < 0.05.
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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