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Table 4 Multivariable linear regression. PWV as a function of the proteins with factor loadings (> 0.4) on principal component 3. Established risk factors of atherosclerosis are included in the multivariable model

From: IGFBP-1 and IGFBP-2 are associated with a decreased pulse-wave velocity in young, healthy adults

  R2 β (95% CI) p value
TFF3 + Model 1 0.063 0.036 (− 0.019; 0.90) 0.20
GDF-15 + Model 1 0.062 0.11 (− 0.062;− 0.029) 0.20
RARRES2 + Model 1 0.065 0.23 (0.0081;0.45) 0.058
IGFBP-2 + Model 1 0.069 − 0.18 (− 0.29;− 0.065) 0.0022*
CD166 + Model 1 0.062 0.18 (− 0.087;0.44) 0.19
IGFBP-1 + Model 1 0.068 − 0.10 (− 0.18;− 0.017) 0.018*
OPG + Model 1 0.061 0.091 (− 0.12;0.30) 0.39
MMP-3 + Model 1 0.060 − 0.0021 (− 0.12;0.12) 0.98
AZU1 + Model 1 0.061 − 0.029 (− 0.17;11) 0.68
ST2 + Model 1 0.062 − 0.014 (− 0.13;0.10) 0.81
CCL15 + Model 1   0.12 (− 0.0069;0.25) 0.062
  1. Model 1 includes age, sex, body fat%, Apolipoprotein B/Apolipoprotein A-1 ratio, Homeostatic model assessment insulin resistance (HOMA-IR) and C-reactive protein (CRP). TFF3 = Trefoil factor 3. GDF-15 = Growth/differentiation factor 15. RARRES2 = Retinoic acid receptor responder protein 2. IGFBP-2 = Insulin-like growth factor-binding protein 2. CD166 = CD166 antigen. IGFBP-1 = Insulin-like growth factor-binding protein 1. OPG = Osteoprotegrin. MMP3 = Matrix metalloproteinase-3. AZU1 = Azurocidin. ST2 = ST2 protein. CCL15 = C–C motif chemokine 15. * indicates a p value < 0.05.