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Table 3 Multivariable linear regression: Vascular measurements as a function of principal components and established risk factors of cardiovascular disease

From: IGFBP-1 and IGFBP-2 are associated with a decreased pulse-wave velocity in young, healthy adults

  PWV (R2: 0.071) AIX (R2: 0.041) cIMT (R2: 0.019)
β (95% CI) p β (95% CI) p β (95% CI) p
PC 1 − 0.067 (− 0.15;0.020) 0.17 − 0.040 (− 0.13;0.052) 0.66 0.079 (− 0.10;0.043) 0.097
PC 2 0.013 (− 0.066;0.093) 0.76 0.032 (− 0.051;0.12) 0.48 − 0.040 (− 0.077;0.069) 0.35
PC 3 0.11 (0.027;0.20) 0.023* 0.065 (− 0.024;0.15) 0.42 − 0.013 (− 0.042;0.0.11) 0.71
Age 0.091 (0.051;0.13)  < 0.001* 0.075 (0.032;0.12)  < 0.001* 0.045 (0.011;0.080) 0.041*
Sex 0.10 (− 0.11;0.29) 0.38 0.098 (− 0.12;0.31) 0.57 − 0.041 (− 0.15;0.18) 0.67
Body fat% 0.10 (0.021;0.16) 0.022* 0.086 (− 0.0011;0.17) 0.13 − 0.0091 (− 0.014;0.13) 0.78
Apo B/Apo A1 0.044 (− 0.043;0.13) 0.33 − 0.00075 (− 0.091;0.093) 0.98 0.077 (− 0.052;0.088) 0.11
HOMA− IR − 0.067 (− 0.11;0.022) 0.16 − 0.059 (− 0.16;0.041) 0.24 − 0.036 (− 0.079;0.056) 0.48
CRP 0.012 (− 0.81;0.11) 0.80 0.061 (− 0.038;0.16) 0.23 0.015 (− 0.087;0.17) 0.78
  1. Variables are separated on sex and z-score transformed before inclusion in the multivariable model. PWV = Pulse-wave velocity. AIX = Augmentation index. cIMT = carotid intima media thickness. β = Beta coefficient. PC = Principal component. Apo B/ApoA-1 = Apolipoprotein B/Apolipoprotein A-1 ratio. TG = Triglycerides. HOMA-IR = Homeostatic model assessment insulin resistance. CRP = C-reactive protein. * indicates a p value < 0.05