Table 3 Major adverse clinical events

Any death

12.6 (11.4, 13.7)

7.9 (6.6, 9.2)

15.1 (13.1, 17.1)

25.2 (20.2, 30.3)

< 0.001

Heart failure hospitalization

6.7 (5.8, 7.6)

4.5 (3.4, 5.5)

7.9 (6.3, 9.4)

13.9 (9.8, 18.1)

0.014

Any death or heart failure hospitalization

16.3 (14.9, 17.7)

10.7 (9.2, 12.3)

19.5 (17.0, 22.0)

33.4 (26.9, 39.8)

< 0.001

Progression to severe aortic stenosis*

3.9 (3.1, 4.7)

4.3 (3.1, 5.5)

3.5 (2.3, 4.7)

3.2 (0.8, 5.5)

0.014

AVR

2.5 (1.9, 3.0)

3.0 (2.2, 3.9)

1.9 (1.2, 2.7)

1.9 (0.5, 3.4)

0.001

Any death, heart failure hospitalization, or AVR

18.4 (16.9, 20.0)

13.1 (11.3, 15.0)

21.1 (18.5, 23.7)

35.4 (28.7, 42.2)

< 0.001

Myocardial infarction

2.3 (1.8, 2.8)

1.5 (0.9, 2.1)

3.6 (2.5, 4.6)

1.3 (0.2, 2.5)

0.002

Stroke

2.0 (1.5, 2.5)

1.8 (1.2, 2.5)

2.1 (1.3, 2.8)

2.8 (1.0, 4.5)

0.824

Any death

10.8 (9.7, 12.0)

7.0 (5.8, 8.2)

13.0 (11.0, 14.9)

23.2 (17.8, 28.5)

< 0.001

Heart failure hospitalization

6.2 (5.4, 7.1)

4.4 (3.3, 5.4)

7.2 (5.7, 8.8)

13.6 (9.1, 18.1)

0.018

Any death or heart failure hospitalization

14.3 (13.0, 15.7)

9.8 (8.2, 11.3)

16.9 (14.6, 19.3)

30.7 (24.0, 37.5)

< 0.001

Progression to severe aortic stenosis

3.9 (3.0, 4.7)

4.4 (3.2, 5.6)

3.3 (2.1, 4.5)

3.2 (0.6, 5.7)

0.012

AVR

2.5 (1.9, 3.0)

3.1 (2.2, 3.9)

1.9 (1.1, 2.6)

2.0 (0.4, 3.6)

0.003

Any death, heart failure hospitalization, or AVR

16.4 (14.9, 17.9)

12.1 (10.4, 13.9)

18.5 (15.9, 21.0)

33.1 (25.9, 40.3)

< 0.001

Myocardial infarction

2.2 (1.7, 2.7)

1.4 (0.9, 2.0)

3.5 (2.5, 4.6)

1.3 (0.03, 2.6)

0.002

Stroke

2.0 (1.5, 2.5)

1.9 (1.2, 2.6)

1.9 (1.1, 2.6)

3.0 (1.0, 5.0)

0.657