Skip to main content

Table 2 Echocardiographic data

From: Natural history observations in moderate aortic stenosis

  All patients
N = 729
NYHA I
N = 306
NYHA II
N = 309
NYHA III or IV
N = 114
p
Peak aortic velocity (m/s) 2.1 (1.7, 2.6) 2.3 (1.9, 2.8) 2.0 (1.6, 2.3) 1.8 (1.5, 2.2) < 0.001
Mean aortic gradient (mmHg) 9.1 (5.9, 14.0) 11.8 (7.6, 16.5) 8.0 (5.3, 11.8) 6.4 (4.4, 11.1) < 0.001
Aortic valve area (cm2) 1.51 (1.34, 1.73) 1.48 (1.30, 1.70) 1.55 (1.37, 1.74) 1.57 (1.38, 1.75) 0.004
Aortic valve area index (cm2/ m2) 0.79 (0.69, 0.89) 0.76 (0.68, 0.86) 0.80 (0.71, 0.91) 0.79 (0.70, 0.90) 0.002
Dimensionless index 0.44 (0.39, 0.47) 0.43 (0.38, 0.47) 0.44 (0.40, 0.47) 0.44 (0.38, 0.48) 0.196
Stroke volume index (ml/m2) 33.8 (25.6, 41.2) 37.1 (30.0, 44.3) 31.4 (25.1, 39.5) 28.2 (23.0, 36.0) < 0.001
Stroke volume index <35 ml/m2 357 (54.3) 104 (38.5) 178 (62.7) 75 (72.1) < 0.001
Left ventricular EDD (cm) 4.8 (4.2, 5.4) 4.5 (4.0, 5.1) 4.8 (4.2, 5.4) 5.4 (4.9, 6.0) < 0.001
Left ventricular mass index (g/m2) 112 (91, 137) 101 (83, 124) 116 (96, 139) 132 (108, 161) < 0.001
Left ventricular ejection fraction (%) 58 (45, 63) 60 (58, 65) 55 (40, 63) 38 (23, 58) < 0.001
Left ventricular ejection fraction <50 % 207 (28.4) 23 (7.5) 112 (36.2) 72 (63.2) < 0.001
E/e’ 12.0 (9.0, 16.0) 11.0 (8.5, 15.0) 12.0 (9.0, 17.0) 13.0 (10.9, 18.0) 0.006
Left atrial volume index (ml/ m2) 37 (29, 49) 34 (27, 46) 36 (29, 50) 45 (34, 56) < 0.001
RV systolic pressure (mmHg) 35 (28, 44) 33 (27, 40) 36 (28, 46) 43 (36, 51) < 0.001
≥ moderate MR 61 (8.4) 10 (3.3) 34 (11.1) 17 (14.9) < 0.001
≥ moderate TR 96 (13.5) 31 (10.4) 38 (12.7) 27 (24.3) 0.001
≥ moderate RV dysfunction 33 (4.7) 2 (0.7) 13 (4.3) 18 (16.8) < 0.001
  1. Data are reported as median (IQR) or no. (%). EDD, end-diastolic dimension; LV, left ventricle; MR, mitral regurgitation; NYHA, New York Heart Association; RV, right ventricular; TR, tricuspid regurgitation