Table 2 Echocardiographic data
From: Natural history observations in moderate aortic stenosis
|  | All patients N = 729 | NYHA I N = 306 | NYHA II N = 309 | NYHA III or IV N = 114 | p |
|---|---|---|---|---|---|
Peak aortic velocity (m/s) | 2.1 (1.7, 2.6) | 2.3 (1.9, 2.8) | 2.0 (1.6, 2.3) | 1.8 (1.5, 2.2) | < 0.001 |
Mean aortic gradient (mmHg) | 9.1 (5.9, 14.0) | 11.8 (7.6, 16.5) | 8.0 (5.3, 11.8) | 6.4 (4.4, 11.1) | < 0.001 |
Aortic valve area (cm2) | 1.51 (1.34, 1.73) | 1.48 (1.30, 1.70) | 1.55 (1.37, 1.74) | 1.57 (1.38, 1.75) | 0.004 |
Aortic valve area index (cm2/ m2) | 0.79 (0.69, 0.89) | 0.76 (0.68, 0.86) | 0.80 (0.71, 0.91) | 0.79 (0.70, 0.90) | 0.002 |
Dimensionless index | 0.44 (0.39, 0.47) | 0.43 (0.38, 0.47) | 0.44 (0.40, 0.47) | 0.44 (0.38, 0.48) | 0.196 |
Stroke volume index (ml/m2) | 33.8 (25.6, 41.2) | 37.1 (30.0, 44.3) | 31.4 (25.1, 39.5) | 28.2 (23.0, 36.0) | < 0.001 |
Stroke volume index <35 ml/m2 | 357 (54.3) | 104 (38.5) | 178 (62.7) | 75 (72.1) | < 0.001 |
Left ventricular EDD (cm) | 4.8 (4.2, 5.4) | 4.5 (4.0, 5.1) | 4.8 (4.2, 5.4) | 5.4 (4.9, 6.0) | < 0.001 |
Left ventricular mass index (g/m2) | 112 (91, 137) | 101 (83, 124) | 116 (96, 139) | 132 (108, 161) | < 0.001 |
Left ventricular ejection fraction (%) | 58 (45, 63) | 60 (58, 65) | 55 (40, 63) | 38 (23, 58) | < 0.001 |
Left ventricular ejection fraction <50 % | 207 (28.4) | 23 (7.5) | 112 (36.2) | 72 (63.2) | < 0.001 |
E/e’ | 12.0 (9.0, 16.0) | 11.0 (8.5, 15.0) | 12.0 (9.0, 17.0) | 13.0 (10.9, 18.0) | 0.006 |
Left atrial volume index (ml/ m2) | 37 (29, 49) | 34 (27, 46) | 36 (29, 50) | 45 (34, 56) | < 0.001 |
RV systolic pressure (mmHg) | 35 (28, 44) | 33 (27, 40) | 36 (28, 46) | 43 (36, 51) | < 0.001 |
≥ moderate MR | 61 (8.4) | 10 (3.3) | 34 (11.1) | 17 (14.9) | < 0.001 |
≥ moderate TR | 96 (13.5) | 31 (10.4) | 38 (12.7) | 27 (24.3) | 0.001 |
≥ moderate RV dysfunction | 33 (4.7) | 2 (0.7) | 13 (4.3) | 18 (16.8) | < 0.001 |