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Table 3 Characteristics of non cardiac iron overloaded patients, with or without a > 15% relative worsening in GLS during follow-up period

From: Left ventricular deformation mechanics over time in patients with thalassemia major with and without iron overload

 

 < 15% relative worsening in GLS

 > 15% relative worsening in GLS

Group 1a (24 pts)

Group 1b (8 pts)

Baseline

Follow-up

p

Δ (%)

Baseline

Follow-up

p

Δ (%)

Group 1a versus 1b Follow-up

Group 1a versus 1b Δ%

P

p

T2* (msec)

34 ± 4

36 ± 3

0.12

6

34 ± 4

31 ± 5

0.40

− 8

0.06

0.12

Ferritin

1190 ± 1573

1295 ± 1998

0.64

43

674 ± 642

263 ± 103

0.15

− 39

0.25

0.18

Echocardiographic data

Conventional

 LVEF (%)

62 ± 5

63 ± 3

0.47

2

65 ± 3

63 ± 3

0.046

− 3

0.75

0.09

 LVEDD (mm)

50 ± 4

49 ± 4

0.06

− 2

47 ± 5

47 ± 6

1.00

0

0.54

0.37

 LVESD (mm)

32 ± 4

31 ± 3

0.35

− 1

29 ± 4

30 ± 5

0.74

2

0.44

0.51

 IVS (mm)

8.5 ± 0.9

8.6 ± 0.9

0.58

2

8.5 ± 1.2

8.9 ± 1.0

0.44

6

0.51

0.44

 E/A

1.4 ± 0.3

1.4 ± 0.2

0.66

5

1.7 ± 1.1

1.5 ± 0.9

0.28

− 9

0.66

0.20

 RVSm (cm/sec)

15 ± 1

15 ± 2

0.56

− 2

15 ± 3

16 ± 1

0.41

14

0.19

0.09

Deformational

 Circumferential strain (%)

− 21.0 ± 3.9

− 22.8 ± 5.4

0.15

9

− 21.9 ± 4.3

− 20.7 ± 6.1

0.63

− 5

0.66

0.21

 Circumferential strain rate

− 1.2 ± 0.2

− 1.4 ± 0.4

0.10

18

− 1.3 ± 0.2

− 1.2 ± 0.1

0.10

− 14

0.86

0.06

 Global Longitudinal strain (%)

− 21.3 ± 2.1

− 22.4 ± 2.2

0.05

6

− 24.5 ± 3.0*

− 19.2 ± 2.4

0.01

− 22

0.004

0.001

 Mean Longitudinal strain rate

− 1.2 ± 0.2

− 1.3 ± 0.2

0.14

7

− 1.4 ± 0.3

− 1.0 ± 0.1

0.01

− 23

0.05

0.43

  1. LVEF left ventricular ejection fraction, GLS left ventricular global longitudinal strain, LVEDD left ventricular end-diastolic diameter, LVESD left ventricular end-systolic diameter, IVS intraventricular septum thickness, E/A early to atrial trans-mitral flow ratio, RVSm right ventricular basal myocardial systolic velocity
  2. *p = 0.02 compared to the corresponding value of Group1a at baseline