|  < 15% relative worsening in GLS |  > 15% relative worsening in GLS | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Group 1a (24 pts) | Group 1b (8 pts) | |||||||||
Baseline | Follow-up | p | Δ (%) | Baseline | Follow-up | p | Δ (%) | Group 1a versus 1b Follow-up | Group 1a versus 1b Δ% | |
P | p | |||||||||
T2* (msec) | 34 ± 4 | 36 ± 3 | 0.12 | 6 | 34 ± 4 | 31 ± 5 | 0.40 | − 8 | 0.06 | 0.12 |
Ferritin | 1190 ± 1573 | 1295 ± 1998 | 0.64 | 43 | 674 ± 642 | 263 ± 103 | 0.15 | − 39 | 0.25 | 0.18 |
Echocardiographic data | ||||||||||
Conventional | ||||||||||
 LVEF (%) | 62 ± 5 | 63 ± 3 | 0.47 | 2 | 65 ± 3 | 63 ± 3 | 0.046 | − 3 | 0.75 | 0.09 |
 LVEDD (mm) | 50 ± 4 | 49 ± 4 | 0.06 | − 2 | 47 ± 5 | 47 ± 6 | 1.00 | 0 | 0.54 | 0.37 |
 LVESD (mm) | 32 ± 4 | 31 ± 3 | 0.35 | − 1 | 29 ± 4 | 30 ± 5 | 0.74 | 2 | 0.44 | 0.51 |
 IVS (mm) | 8.5 ± 0.9 | 8.6 ± 0.9 | 0.58 | 2 | 8.5 ± 1.2 | 8.9 ± 1.0 | 0.44 | 6 | 0.51 | 0.44 |
 E/A | 1.4 ± 0.3 | 1.4 ± 0.2 | 0.66 | 5 | 1.7 ± 1.1 | 1.5 ± 0.9 | 0.28 | − 9 | 0.66 | 0.20 |
 RVSm (cm/sec) | 15 ± 1 | 15 ± 2 | 0.56 | − 2 | 15 ± 3 | 16 ± 1 | 0.41 | 14 | 0.19 | 0.09 |
Deformational | ||||||||||
 Circumferential strain (%) | − 21.0 ± 3.9 | − 22.8 ± 5.4 | 0.15 | 9 | − 21.9 ± 4.3 | − 20.7 ± 6.1 | 0.63 | − 5 | 0.66 | 0.21 |
 Circumferential strain rate | − 1.2 ± 0.2 | − 1.4 ± 0.4 | 0.10 | 18 | − 1.3 ± 0.2 | − 1.2 ± 0.1 | 0.10 | − 14 | 0.86 | 0.06 |
 Global Longitudinal strain (%) | − 21.3 ± 2.1 | − 22.4 ± 2.2 | 0.05 | 6 | − 24.5 ± 3.0* | − 19.2 ± 2.4 | 0.01 | − 22 | 0.004 | 0.001 |
 Mean Longitudinal strain rate | − 1.2 ± 0.2 | − 1.3 ± 0.2 | 0.14 | 7 | − 1.4 ± 0.3 | − 1.0 ± 0.1 | 0.01 | − 23 | 0.05 | 0.43 |