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Table 3 Characteristics of non cardiac iron overloaded patients, with or without a > 15% relative worsening in GLS during follow-up period

From: Left ventricular deformation mechanics over time in patients with thalassemia major with and without iron overload

   < 15% relative worsening in GLS  > 15% relative worsening in GLS
Group 1a (24 pts) Group 1b (8 pts)
Baseline Follow-up p Δ (%) Baseline Follow-up p Δ (%) Group 1a versus 1b Follow-up Group 1a versus 1b Δ%
P p
T2* (msec) 34 ± 4 36 ± 3 0.12 6 34 ± 4 31 ± 5 0.40 − 8 0.06 0.12
Ferritin 1190 ± 1573 1295 ± 1998 0.64 43 674 ± 642 263 ± 103 0.15 − 39 0.25 0.18
Echocardiographic data
Conventional
 LVEF (%) 62 ± 5 63 ± 3 0.47 2 65 ± 3 63 ± 3 0.046 − 3 0.75 0.09
 LVEDD (mm) 50 ± 4 49 ± 4 0.06 − 2 47 ± 5 47 ± 6 1.00 0 0.54 0.37
 LVESD (mm) 32 ± 4 31 ± 3 0.35 − 1 29 ± 4 30 ± 5 0.74 2 0.44 0.51
 IVS (mm) 8.5 ± 0.9 8.6 ± 0.9 0.58 2 8.5 ± 1.2 8.9 ± 1.0 0.44 6 0.51 0.44
 E/A 1.4 ± 0.3 1.4 ± 0.2 0.66 5 1.7 ± 1.1 1.5 ± 0.9 0.28 − 9 0.66 0.20
 RVSm (cm/sec) 15 ± 1 15 ± 2 0.56 − 2 15 ± 3 16 ± 1 0.41 14 0.19 0.09
Deformational
 Circumferential strain (%) − 21.0 ± 3.9 − 22.8 ± 5.4 0.15 9 − 21.9 ± 4.3 − 20.7 ± 6.1 0.63 − 5 0.66 0.21
 Circumferential strain rate − 1.2 ± 0.2 − 1.4 ± 0.4 0.10 18 − 1.3 ± 0.2 − 1.2 ± 0.1 0.10 − 14 0.86 0.06
 Global Longitudinal strain (%) − 21.3 ± 2.1 − 22.4 ± 2.2 0.05 6 − 24.5 ± 3.0* − 19.2 ± 2.4 0.01 − 22 0.004 0.001
 Mean Longitudinal strain rate − 1.2 ± 0.2 − 1.3 ± 0.2 0.14 7 − 1.4 ± 0.3 − 1.0 ± 0.1 0.01 − 23 0.05 0.43
  1. LVEF left ventricular ejection fraction, GLS left ventricular global longitudinal strain, LVEDD left ventricular end-diastolic diameter, LVESD left ventricular end-systolic diameter, IVS intraventricular septum thickness, E/A early to atrial trans-mitral flow ratio, RVSm right ventricular basal myocardial systolic velocity
  2. *p = 0.02 compared to the corresponding value of Group1a at baseline