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Table 2 Echocardiographic and MRI data at baseline and during follow-up

From: Left ventricular deformation mechanics over time in patients with thalassemia major with and without iron overload

  T2* > 25 ms (n = 32) Group1 P T2* ≤ 25 ms (n = 8) Group2 P
Βaseline Follow-up Baseline Follow-up
Echocardiographic data
Conventional
 LVEF (%) 62 ± 5 63 ± 3 0.60 58 ± 10 56 ± 11 0.17
 LVEDD (mm) 49 ± 4 48 ± 4 0.10 49 ± 4 48 ± 4 0.36
 LVESD (mm) 31 ± 4 30 ± 4 0.72 31 ± 6 32 ± 6 0.10
 IVS (mm) 8.6 ± 0.9 8.7 ± 0.9 0.50 8.1 ± 0.9 8.5 ± 0.9 0.08
 E/A 1.5 ± 0.6 1.4 ± 0.5 0.93 1.5 ± 0.6 1.4 ± 0.3 0.68
 RVSm (cm/sec) 15.0 ± 1.9 15.1 ± 1.8 0.84 14.8 ± 2.3 14.6 ± 1.7 0.81
Deformational
 Circumferential strain (%) − 22 ± 5 − 22 ± 5 0.71 − 20 ± 6 − 18 ± 6 0.22
 Circumferential strain rate − 1.4 ± 0.9 − 1.4 ± 0.4 0.65 − 1.2 ± 0.4 − 1.2 ± 0.5 0.64
 Global Longitudinal strain (%) − 22 ± 3 − 21 ± 3 0.24 − 18 ± 5 * − 17 ± 4 0.38
 Mean Longitudinal strain rate − 1.2 ± 0.3 − 1.2 ± 0.2 0.37 − 1.0 ± 0.3 ** − 1.0 ± 0.2 0.68
 T2* (msec) 33 ± 3 34 ± 4 0.52 16 ± 9 *** 17 ± 9 0.55
  1. LVEF left ventricular ejection fraction, LVEDD left ventricular end-diastolic diameter, LVESD left ventricular end-systolic diameter, IVS intraventricular septum thickness, E/A early to atrial transmitral flow ratio, RVSm right ventricular basal myocardial systolic velocity
  2. *p = 0.01; **p = 0.04; ***p = 0.01, all compared to the baseline values of the Group1