Left ventricular deformation mechanics over time in patients with thalassemia major with and without iron overload

Table 2 Echocardiographic and MRI data at baseline and during follow-up

	T2* > 25 ms (n = 32) Group1		P	T2* ≤ 25 ms (n = 8) Group2		P
	Βaseline	Follow-up	P	Baseline	Follow-up	P
Echocardiographic data
Conventional
LVEF (%)	62 ± 5	63 ± 3	0.60	58 ± 10	56 ± 11	0.17
LVEDD (mm)	49 ± 4	48 ± 4	0.10	49 ± 4	48 ± 4	0.36
LVESD (mm)	31 ± 4	30 ± 4	0.72	31 ± 6	32 ± 6	0.10
IVS (mm)	8.6 ± 0.9	8.7 ± 0.9	0.50	8.1 ± 0.9	8.5 ± 0.9	0.08
E/A	1.5 ± 0.6	1.4 ± 0.5	0.93	1.5 ± 0.6	1.4 ± 0.3	0.68
RVSm (cm/sec)	15.0 ± 1.9	15.1 ± 1.8	0.84	14.8 ± 2.3	14.6 ± 1.7	0.81
Deformational
Circumferential strain (%)	− 22 ± 5	− 22 ± 5	0.71	− 20 ± 6	− 18 ± 6	0.22
Circumferential strain rate	− 1.4 ± 0.9	− 1.4 ± 0.4	0.65	− 1.2 ± 0.4	− 1.2 ± 0.5	0.64
Global Longitudinal strain (%)	− 22 ± 3	− 21 ± 3	0.24	− 18 ± 5 *	− 17 ± 4	0.38
Mean Longitudinal strain rate	− 1.2 ± 0.3	− 1.2 ± 0.2	0.37	− 1.0 ± 0.3 **	− 1.0 ± 0.2	0.68
T2* (msec)	33 ± 3	34 ± 4	0.52	16 ± 9 ***	17 ± 9	0.55

LVEF left ventricular ejection fraction, LVEDD left ventricular end-diastolic diameter, LVESD left ventricular end-systolic diameter, IVS intraventricular septum thickness, E/A early to atrial transmitral flow ratio, RVSm right ventricular basal myocardial systolic velocity
^*p = 0.01; **p = 0.04; ***p = 0.01, all compared to the baseline values of the Group1

ISSN: 1471-2261