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Table 3 DNA methylation differences in eight CpG sites within the ABCA1-A locus in the two groups

From: Effect of ABCA1 promoter methylation on premature coronary artery disease and its relationship with inflammation

Item

Control group

(n = 90)

PCAD group

(n = 90)

t

P value

CpG1 (%)

35.40 ± 3.87

43.54 ± 5.78

11.092

 < 0.001

CpG2 (%)

25.61 ± 2.93

32.21 ± 5.99

9.396

 < 0.001

CpG3 (%)

58.84 ± 6.53

71.75 ± 5.69

14.137

 < 0.001

CpG4 (%)

39.76 ± 4.73

49.65 ± 8.38

9.751

 < 0.001

CpG5 (%)

37.35 ± 8.36

44.03 ± 8.56

5.296

 < 0.001

CpG6 (%)

29.93 ± 4.29

37.64 ± 5.68

10.282

 < 0.001

CpG7 (%)

34.95 ± 4.20

42.43 ± 5.80

9.912

 < 0.001

CpG8 (%)

27.11 ± 2.71

32.83 ± 4.88

9.714

 < 0.001

Mean ABCA1 promoter methylation (%)

36.05 ± 2.99

44.24 ± 3.66

16.429

 < 0.001

ABCA1 concentration (ng/mL)

3.35 (3.02–3.95)

3.15 (2.73–3.74)

2.458

0.014

  1. Variables are presented as means ± standard deviations and median (interquartile spacing)