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Table 3 DNA methylation differences in eight CpG sites within the ABCA1-A locus in the two groups

From: Effect of ABCA1 promoter methylation on premature coronary artery disease and its relationship with inflammation

Item Control group
(n = 90)
PCAD group
(n = 90)
t P value
CpG1 (%) 35.40 ± 3.87 43.54 ± 5.78 11.092  < 0.001
CpG2 (%) 25.61 ± 2.93 32.21 ± 5.99 9.396  < 0.001
CpG3 (%) 58.84 ± 6.53 71.75 ± 5.69 14.137  < 0.001
CpG4 (%) 39.76 ± 4.73 49.65 ± 8.38 9.751  < 0.001
CpG5 (%) 37.35 ± 8.36 44.03 ± 8.56 5.296  < 0.001
CpG6 (%) 29.93 ± 4.29 37.64 ± 5.68 10.282  < 0.001
CpG7 (%) 34.95 ± 4.20 42.43 ± 5.80 9.912  < 0.001
CpG8 (%) 27.11 ± 2.71 32.83 ± 4.88 9.714  < 0.001
Mean ABCA1 promoter methylation (%) 36.05 ± 2.99 44.24 ± 3.66 16.429  < 0.001
ABCA1 concentration (ng/mL) 3.35 (3.02–3.95) 3.15 (2.73–3.74) 2.458 0.014
  1. Variables are presented as means ± standard deviations and median (interquartile spacing)