Table 3 Allele and genotype distribution of HPA polymorphisms in CAD patients and healthy controls
dbSNP | Alleles/genotypes | CAD (n = 200) N (%) | Control (n = 100) N (%) | χ2 | P value | OR (95% CI) |
|---|---|---|---|---|---|---|
HPA1 | T (a) | 363 (90.7) | 178 (89) | 0.460 | 0.497 | 1.212 (0.69–2.11) |
C (b) | 37 (9.3) | 22 (11) | – | – | 0.824 (0.47–1.43) | |
TT (aa) | 163 (81.5) | 79 (78) | 0.516 | 0.472 | 1.242 (0.68–2.24) | |
CT (ab) | 37 (18.5) | 22 (22) | – | – | 0.804 (0.44–1.45) | |
CC (bb) | 0 (0) | 0 (0) | – | – | – | |
HWE |  |  | P = 0.216 |  |  |  |
HPA2 | C (a) | 350 (87.5) | 178 (89) | 0.284 | 0.594 | 0.865 (0.50–1.47) |
T (b) | 50 (12.5) | 22 (11) | – | – | 1.155 (0.67–1.96) | |
CC (aa) | 153(76.5) | 79 (79) | 0.303 | 0.859 | 0.865 (0.48–1.54) | |
CT (ab) | 44 (22) | 20 (20) | – | – | 1.128 (0.62–2.04) | |
TT (bb) | 3 (1.5) | 1 (1) | – | – | 1.507 (0.15–14.68) | |
HWE |  |  | P = 0.830 |  |  |  |
HPA3 | T (a) | 235 (58.8) | 118 (59) | 0.003 | 0.953 | 0.989 (0.70–1.39) |
G (b) | 165 (41.2) | 82 (41) | – | – | 1.010 (0.71–1.42) | |
TT (aa) | 74 (37) | 38 (38) | 0.061 | 0.969 | 0.958 (0.58–1.57) | |
GT (ab) | 87 (43.5) | 42 (42) | – | – | 1.063 (0.65–1.72) | |
GG (bb) | 39 (19.5) | 20 (20) | – | – | 0.968 (0.53–1.76) | |
HWE |  |  | P = 0.187 |  |  |  |
HPA4 | G (a) | 400 (100) | 200 (100) | – | – | – |
A (b) | 0 (0) | 0 (0) | – | – | – | |
GG (aa) | 200 (100) | 100 | – | – | – | |
GA (ab) | 0 (0) | 0 | – | – | – | |
AA (bb) | 0 (0) | 0 | – | – | – | |
HWE |  |  | P = 0 |  |  |  |
HPA5 | G (a) | 363 (90.7) | 183 (91.5) | 0.091 | 0.762 | 0.911 (0.49–1.66) |
A (b) | 37 (9.2) | 17 (8.5) | – | – | 1.097 (0.60–2.00) | |
GG (aa) | 167 (83.5) | 85 (85) | 0.125 | 0.939 | 0.893 (0.45–1.73) | |
AG (ab) | 29 (14.5) | 13 (13) | – | – | 1.135 (0.56–2.29) | |
AA (bb) | 4 (2) | 2 (2) | – | – | 0.951 (0.17–5.28) | |
HWE |  |  | P = 0.1 |  |  |  |
HPA6 | G (a) | 400 (100) | 200 (100) | – | – | – |
A (b) | 0 (0) | 0 (0) | – | – | – | |
GG (aa) | 200 (100) | 100 | – | – | – | |
GA (ab) | 0 (0) | 0 | – | – | – | |
AA (bb) | 0 (0) | 0 | – | – | – | |
HWE |  |  | P = 0 |  |  |  |
HPA9 | G (a) | 400 (100) | 200 (100) | – | – | – |
A (b) | 0 (0) | 0 (0) | – | – | – | |
GG (aa) | 200 (100) | 100 | – | – | – | |
GA (ab) | 0 (0) | 0 | – | – | – | |
AA (bb) | 0 (0) | 0 | – | – | – | |
HWE |  |  | P = 0 |  |  |  |
HPA15 | C (a) | 188 (47) | 88 (44) | 0.483 | 0.487 | 1.128 (0.80–1.58) |
A (b) | 212 (53) | 112 (56) | – | – | 0.886 (0.62–1.24) | |
CC (aa) | 43 (21.5) | 21 (21) | 1.033 | 0.596 | 1.030 (0.57–1.85) | |
AC (ab) | 102 (51) | 46 (46) | – | – | 1.221 (0.75–1.97) | |
AA (bb) | 55 (27.5) | 33 (33) | – | – | 0.770 (0.45–1.29) | |
HWE |  |  | P = 0.505 |  |  |  |