Skip to main content

Table 3 Allele and genotype distribution of HPA polymorphisms in CAD patients and healthy controls

From: Association of human platelet alloantigens encoding gene polymorphisms with the risk of Coronary artery disease in Iranian patients

dbSNP Alleles/genotypes CAD (n = 200)
N (%)
Control (n = 100)
N (%)
χ2 P value OR (95% CI)
HPA1 T (a) 363 (90.7) 178 (89) 0.460 0.497 1.212 (0.69–2.11)
C (b) 37 (9.3) 22 (11) 0.824 (0.47–1.43)
TT (aa) 163 (81.5) 79 (78) 0.516 0.472 1.242 (0.68–2.24)
CT (ab) 37 (18.5) 22 (22) 0.804 (0.44–1.45)
CC (bb) 0 (0) 0 (0)
HWE    P = 0.216    
HPA2 C (a) 350 (87.5) 178 (89) 0.284 0.594 0.865 (0.50–1.47)
T (b) 50 (12.5) 22 (11) 1.155 (0.67–1.96)
CC (aa) 153(76.5) 79 (79) 0.303 0.859 0.865 (0.48–1.54)
CT (ab) 44 (22) 20 (20) 1.128 (0.62–2.04)
TT (bb) 3 (1.5) 1 (1) 1.507 (0.15–14.68)
HWE    P = 0.830    
HPA3 T (a) 235 (58.8) 118 (59) 0.003 0.953 0.989 (0.70–1.39)
G (b) 165 (41.2) 82 (41) 1.010 (0.71–1.42)
TT (aa) 74 (37) 38 (38) 0.061 0.969 0.958 (0.58–1.57)
GT (ab) 87 (43.5) 42 (42) 1.063 (0.65–1.72)
GG (bb) 39 (19.5) 20 (20) 0.968 (0.53–1.76)
HWE    P = 0.187    
HPA4 G (a) 400 (100) 200 (100)
A (b) 0 (0) 0 (0)
GG (aa) 200 (100) 100
GA (ab) 0 (0) 0
AA (bb) 0 (0) 0
HWE    P = 0    
HPA5 G (a) 363 (90.7) 183 (91.5) 0.091 0.762 0.911 (0.49–1.66)
A (b) 37 (9.2) 17 (8.5) 1.097 (0.60–2.00)
GG (aa) 167 (83.5) 85 (85) 0.125 0.939 0.893 (0.45–1.73)
AG (ab) 29 (14.5) 13 (13) 1.135 (0.56–2.29)
AA (bb) 4 (2) 2 (2) 0.951 (0.17–5.28)
HWE    P = 0.1    
HPA6 G (a) 400 (100) 200 (100)
A (b) 0 (0) 0 (0)
GG (aa) 200 (100) 100
GA (ab) 0 (0) 0
AA (bb) 0 (0) 0
HWE    P = 0    
HPA9 G (a) 400 (100) 200 (100)
A (b) 0 (0) 0 (0)
GG (aa) 200 (100) 100
GA (ab) 0 (0) 0
AA (bb) 0 (0) 0
HWE    P = 0    
HPA15 C (a) 188 (47) 88 (44) 0.483 0.487 1.128 (0.80–1.58)
A (b) 212 (53) 112 (56) 0.886 (0.62–1.24)
CC (aa) 43 (21.5) 21 (21) 1.033 0.596 1.030 (0.57–1.85)
AC (ab) 102 (51) 46 (46) 1.221 (0.75–1.97)
AA (bb) 55 (27.5) 33 (33) 0.770 (0.45–1.29)
HWE    P = 0.505    
  1. SNP single nucleotide polymorphism, CAD coronary arthery disease, HWE Hardy–Weinberg equilibrium