Dysregulation of serum miR-361-5p serves as a biomarker to predict disease onset and short-term prognosis in acute coronary syndrome patients

Table 1 Baseline characteristics of the study population

Features	Total individuals (n = 262)	Healthy controls (n = 66)	SCHD patients (n = 78)	ACS patients (n = 118)	P₁ value	P₂ value	P₃ value
Age (years)	65.0 ± 9.7	65.0 ± 11.2	63.8 ± 7.9	65.6 ± 9.7	0.759	0.912	0.430
Gender, male (%)	157 (59.9%)	40 (60.6)	49 (62.8)	68 (57.6)	0.785	0.694	0.468
BMI (kg/m²)	25.0 ± 2.7	24.7 ± 2.3	25.4 ± 3.2	25.0 ± 2.7	0.324	0.792	0.603
TC (mM)	4.7 ± 0.8	4.6 ± 0.5	4.5 ± 0.6	5.0 ± 0.8	0.935	0.006	0.001
TG (mM)	1.8 ± 0.6	1.6 ± 0.6	1.8 ± 0.5	1.8 ± 0.6	0.512	0.087	0.594
HDL-C (mM)	1.2 ± 0.3	1.5 ± 0.2	1.2 ± 0.2	1.2 ± 0.3	< 0.001	< 0.001	0.979
LDL-C (mM)	2.7 ± 0.6	2.5 ± 0.7	2.6 ± 0.4	2.8 ± 0.6	0.247	0.002	0.173
Hypertension (%)	85 (32.4%)	19 (28.8)	24 (30.8)	42 (35.6)	0.796	0.347	0.484
Diabetes (%)	81 (30.9%)	17 (25.8)	25 (32.1)	39 (33.1)	0.408	0.302	0.884
WBC (× 10⁹/L)	8.0 ± 2.6	6.3 ± 1.4	7.6 ± 1.8	9.1 ± 2.6	0.004	< 0.001	< 0.001
cTnI (ng/mL)	0.8 ± 0.9	0.09 ± 0.1	0.2 ± 0.2	1.6 ± 1.2	< 0.001	< 0.001	< 0.001
Gensini score	–	–	47.5 ± 19.5	58.6 ± 24.4	–	–	0.002

P₁: SCHD patients vs. healthy controls; P₂: ACS patients vs. healthy controls; P₃: ACS patients vs. SCHD patients
SCHD stable coronary heart disease, ACS acute coronary syndrome, BMI body mass index, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, WBC white blood cell, cTnI cardiac troponin I

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