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Table 3 Cox proportional hazards models, A (univariable), B and C (multivariable) for time to first of MI/Unstable angina/PCI/CABG during 21 years of follow-up

From: Multi-modality biomarkers in the early prediction of ischaemic heart disease in middle-aged men during a 21-year follow-up

Model

N

Predictors

 

Hazard Ratio

  
    

(95% CI)

p value

AUC (95% CI)

A

707

Framingham score

Risk by 1 unit increase

1.36 (1.24–1.50)

 < 0.0001

0.69 (0.63–0.74)

B

710

HDL cholesterol (mmol/L)

Risk by 0.2 units decrease

1.48 (1.26–1.73)

 < 0.0001

0.71 (0.66–0.77)

  

Hypertension

Yes vs No

2.14 (1.41–3.24)

0.0003

 
  

Total cholesterol (mmol/L)

Risk by 1 unit increase

1.43 (1.17–1.74)

0.0004

 

C

710

HDL cholesterol (mmol/L)

Risk by 0.2 units decrease

1.49 (1.27–1.75)

 < 0.0001

0.72 (0.67–0.78)

  

Hypertension

Yes vs No

2.05 (1.35–3.10)

0.0008

 
  

Total cholesterol (mmol/L)

Risk by 1 unit increase

1.43 (1.17–1.74)

0.0005

 
  

High-sensitivity Troponin-T ≤ 3/3–10/ > 10 (ng/L)

 > 3–10 vs ≤ 3

1.49 (0.90–2.45)

0.12

 
   

 > 10 vs ≤ 3

2.96 (1.35–6.49)

0.0066