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Table 1 Patients characteristics from 1993 by incidence of MI/Unstable angina/PCI/CABG during 21-years of follow-up

From: Multi-modality biomarkers in the early prediction of ischaemic heart disease in middle-aged men during a 21-year follow-up

 

Total (n = 739)

No MI, unstable angina, PCI or CABG (before 20,140,830)

(n = 642)

MI, unstable angina, PCI or CABG (before 20,140,830)

(n = 97)

p value

Framingham score

11.0 (2.2)

11.0 (5.0; 18.0)

n = 707

10.9 (2.1)

11.0 (5.0; 17.0)

n = 616

12.3 (2.1)

12.0 (7.0; 18.0)

n = 91

 < .0001

Total cholesterol (mmol/L)

5.88 (1.04)

5.80 (3.10; 9.90)

n = 739

5.83 (1.03)

5.80 (3.10; 9.10)

n = 642

6.19 (0.99)

6.00 (4.20; 9.90)

n = 97

0.0043

Hyperlipidemia

263 (35.6%)

222 (34.6%)

41 (42.3%)

0.18

HDL cholesterol

1.31 (0.34)

1.30 (0.57; 3.70)

n = 710

1.33 (0.34)

1.30 (0.57; 3.70)

n = 619

1.16 (0.31)

1.10 (0.58; 2.40)

n = 91

 < .0001

Systolic blood pressure (mmHg)

128.9 (17.3)

128.0 (92.0; 198.0)

n = 736

128.0 (17.0)

126.0 (92.0; 198.0)

n = 639

134.4 (17.9)

135.0 (92.0; 178.0)

n = 97

0.0003

Diastolic blood pressure (mmHg)

84.4 (10.6)

84.0 (56.0; 120.0)

n = 736

83.9 (10.5)

82.0 (56.0; 120.0)

n = 639

87.3 (11.0)

88.0 (62.0; 110.0)

n = 97

0.0027

Hypertension

291 (39.4%)

235 (36.6%)

56 (57.7%)

0.0001

Blood pressure lowering medication

44 (6.0%)

29 (4.5%)

15 (15.5%)

0.0004

Smoker

228 (30.9%)

191 (29.8%)

37 (38.1%)

0.12

BMI (kg/m2)

26.2 (3.4)

25.8 (16.6; 41.6)

n = 739

26.1 (3.4)

25.7 (16.6; 41.6)

n = 642

27.0 (3.6)

26.7 (18.5; 38.3)

n = 97

0.022

Fasting plasma glucose (mmol/L)

4.67 (1.26)

4.50 (2.60; 19.20)

n = 736

4.63 (1.16)

4.50 (2.60; 19.20)

n = 639

4.95 (1.80)

4.60 (3.80; 17.60)

n = 97

0.0059

Diabetes

25 (3.4%)

20 (3.1%)

5 (5.2%)

0.44

Sedentary leisure time

112 (15.2%)

92 (14.3%)

20 (20.6%)

0.15

High-sensitivity C-reactive Protein (mg/L)

2.26 (3.60)

1.23 (0.14; 47.06)

n = 739

2.22 (3.47)

1.21 (0.14; 47.06)

n = 642

2.51 (4.40)

1.41 (0.16; 40.25)

n = 97

0.12

hsCRP > 1 mg/L

448 (60.6%)

378 (58.9%)

70 (72.2%)

0.015

hsCRP > 2 mg/L

240 (32.5%)

207 (32.2%)

33 (34.0%)

0.81

hsCRP > 3 mg/L

135 (18.3%)

118 (18.4%)

17 (17.5%)

0.97

NT-proBNP (pg/mL)

33.9 (40.7)

23.7 (5.0; 375.2)

n = 739

33.8 (40.1)

24.0 (5.0; 375.2)

n = 642

34.3 (44.8)

22.1 (5.0; 291.4)

n = 97

0.98

NT-proBNP > 50 pg/mL

132 (17.9%)

117 (18.2%)

15 (15.5%)

0.62

NT-proBNP > 100 pg/mL

41 (5.5%)

36 (5.6%)

5 (5.2%)

1.00

High-sensitivity Troponin-T (ng/L)

5.07 (3.30)

4.04 (3.00; 38.96)

n = 739

4.97 (3.10)

3.98 (3.00; 37.20)

n = 642

5.67 (4.35)

4.49 (3.00; 38.96)

n = 97

0.041

hsTroponin-T > 3 ng/L

507 (68.6%)

431 (67.1%)

76 (78.4%)

0.032

hsTroponin-T > 5 ng/L

265 (35.9%)

225 (35.0%)

40 (41.2%)

0.28

hsTroponin-T > 10 ng/L

39 (5.3%)

29 (4.5%)

10 (10.3%)

0.045

IL-6 (ng/L)

2.77 (3.90)

1.88 (1.50; 87.10)

n = 736

2.70 (3.84)

1.84 (1.50; 87.10)

n = 641

3.21 (4.26)

2.25 (1.50; 36.61)

n = 95

0.023

IL-6 > 8 ng/L

19 (2.6%)

16 (2.5%)

3 (3.2%)

0.91

Number of risk biomarkers (hsCRP > 1,NT-proBNP > 100,hsTroponin-T > 10,IL6 > 8)

0

264 (35.7%)

240 (37.4%)

24 (24.7%)

 

1

408 (55.2%)

349 (54.4%)

59 (60.8%)

 

2

62 (8.4%)

49 (7.6%)

13 (13.4%)

 

3

5 (0.7%)

4 (0.6%)

1 (1.0%)

0.0053

  1. For categorical variables n (%) is presented
  2. For continuous variables Mean (SD) / Median (Min; Max) / n = is presented
  3. For comparison between groups Fisher´s Exact test (lowest 1-sided p-value multiplied by 2) was used for dichotomous variables and the Mantel–Haenszel Chi Square test was used for ordered categorical variables and the Mann–Whitney U-test was used for continuous variables