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Table 4 Clinical outcomes after 18-month follow-up in sustained PPI, intermittent PPI and non-PPI users

From: Intermittent concurrent use of clopidogrel and proton pump inhibitors did not increase risk of adverse clinical outcomes in Chinese patients with coronary artery disease

 

Sustained PPI users

Intermittent PPI users

Non-PPI users

p value

Death

4 (2.0%)

6 (3.2%)

9 (3.6%)

0.589

 Fatal MI

0 (0.5%)

1 (0.5%)

1 (0.4%)

0.612

 Stroke

1 (0.5%)

1 (0.5%)

1 (0.4%)

0.978

 Other cardiovascular

1 (0.5%)

1 (0.5%)

1 (0.4%)

0.978

 Non-cardiovascular

0 (0.5%)

0 (0.0%)

4 (1.6%)

0.043

 Unknown

2 (1.0%)

3 (1.6%)

2 (0.8%)

0.723

Rehospitalization

101 (50.2%)

89 (47.3%)

80 (32.1%)

< 0.001

 MI

0 (0.0%)

3 (1.6%)

3 (1.2%)

0.227

 Angina

46 (22.9%)

26 (13.8%)

29 (11.6%)

0.003

 Stroke

3 (1.5%)

1 (0.5%)

5 (2.0%)

0.429

 GI bleeding

1 (0.5%)

0 (0.0%)

0 (0.0%)

0.337

 Other

51 (25.3%)

59 (47.9%)

43 (17.3%)

0.002

Cardiovascular events

    

 Non-fatal MI

1 (0.5%)

3 (1.6%)

2 (0.8%)

0.512

 Revascularization

11 (5.5%)

3 (1.6%)

6 (2.4%)

0.063

 Stroke

10 (5.0%)

1 (0.5%)

9 (3.6%)

0.036

 GI bleeding

2 (1.0%)

0 (0.0%)

2 (0.8%)

0.417

 Other bleeding

0 (0.0%)

0 (0.0%)

0 (0.0%)

–

  1. GI, gastrointestinal; MI, myocardial infarction; PPI, proton pump inhibitor