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Table 4 Clinical outcomes after 18-month follow-up in sustained PPI, intermittent PPI and non-PPI users

From: Intermittent concurrent use of clopidogrel and proton pump inhibitors did not increase risk of adverse clinical outcomes in Chinese patients with coronary artery disease

  Sustained PPI users Intermittent PPI users Non-PPI users p value
Death 4 (2.0%) 6 (3.2%) 9 (3.6%) 0.589
 Fatal MI 0 (0.5%) 1 (0.5%) 1 (0.4%) 0.612
 Stroke 1 (0.5%) 1 (0.5%) 1 (0.4%) 0.978
 Other cardiovascular 1 (0.5%) 1 (0.5%) 1 (0.4%) 0.978
 Non-cardiovascular 0 (0.5%) 0 (0.0%) 4 (1.6%) 0.043
 Unknown 2 (1.0%) 3 (1.6%) 2 (0.8%) 0.723
Rehospitalization 101 (50.2%) 89 (47.3%) 80 (32.1%) < 0.001
 MI 0 (0.0%) 3 (1.6%) 3 (1.2%) 0.227
 Angina 46 (22.9%) 26 (13.8%) 29 (11.6%) 0.003
 Stroke 3 (1.5%) 1 (0.5%) 5 (2.0%) 0.429
 GI bleeding 1 (0.5%) 0 (0.0%) 0 (0.0%) 0.337
 Other 51 (25.3%) 59 (47.9%) 43 (17.3%) 0.002
Cardiovascular events     
 Non-fatal MI 1 (0.5%) 3 (1.6%) 2 (0.8%) 0.512
 Revascularization 11 (5.5%) 3 (1.6%) 6 (2.4%) 0.063
 Stroke 10 (5.0%) 1 (0.5%) 9 (3.6%) 0.036
 GI bleeding 2 (1.0%) 0 (0.0%) 2 (0.8%) 0.417
 Other bleeding 0 (0.0%) 0 (0.0%) 0 (0.0%)
  1. GI, gastrointestinal; MI, myocardial infarction; PPI, proton pump inhibitor