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Table 3 Laboratory parameters of patients with sustained, intermittent and non-PPI users

From: Intermittent concurrent use of clopidogrel and proton pump inhibitors did not increase risk of adverse clinical outcomes in Chinese patients with coronary artery disease

  Sustained PPI users Intermittent PPI users Non-PPI users p value
N 201 188 249  
Laboratory parameters     
Creatinine (mg/dL) 104.5 ± 70.8 111.3 ± 97.8 103.2 ± 56.7 0.552
Glucose (mmol/L) 5.5 ± 1.8 5.9 ± 2.4 5.7 ± 1.9 0.171
Total cholesterol (mmol/L) 4.22 (3.51, 5.11) 4.48 (3.81, 5.42) 4.47 (3.65, 5.25) 0.597
HDL-C (mmol/L) 1.07 (0.90, 1.32) 1.08 (0.89, 1.29) 1.06 (0.90, 1.26) 0.585
LDL-C (mmol/L) 2.46 (1.98, 3.12) 2.64 (2.14, 3.29) 2.59 (2.08, 3.19) 0.723
Triglycerides (mmol/L) 1.20 (0.94, 1.86) 1.38 (0.94, 2.04) 1.45 (1.05, 2.09) 0.239
Uric acid (µmol/L) 368.0 (311.0, 446.0) 393.0 (319.0, 477.0) 391.0 (329.0, 469.5) 0.916
ALT (U/L) 21.0 (15.0, 33.0) 20.0 (14.0, 35.5) 21.0 (15.0, 32.0) 0.455
AST (U/T) 23.0 (18.0, 38.0) 21.0 (18.0, 34.5) 23.0 (18.0, 29.0) 0.954
CK (U/L) 94.0 (64.0, 162.0) 87.0 (62.5, 136.0) 90.5 (65.0, 168.5) 0.758
CK-MB (U/L) 14.0 (11.0, 20.0) 14.0 (11.0, 19.0) 13.0 (11.0, 17.0) 0.567
hs-CRP (mg/L) 7156.0 (5888.0, 8098.0) 7439.0 (6282.0, 8259.0) 7544.5 (6269.8, 8507.0) 0.228
HbAlc (%) 6.0 (5.6, 6.6) 6.0 (5.6, 7.1) 6.1 (5.6, 7.1) 0.580
NT-proBNP 126.3 (55.1, 674.7) 151.0 (66.4, 587.6) 159.9 (63.2, 697.5) 0.732
TnT-HS 7.4 (4.4, 50.7) 13.2 (5.0, 398.0) 11.1 (5.4, 67.3) 0.439
Hb (g/L) 131.5 ± 19.1 129.4 ± 18.7 134.7 ± 22.5 0.042
Platelet count (× 109/L) 221.6 ± 60.8 235.5 ± 64.3 221.9 ± 62.2 0.059
CYP2C19 genotypes (%) 110 111 115 0.536
 EM 31.8 39.6 42.6  
 IM 50.0 45.0 40.9  
 PM 18.2 15.3 16.5  
  1. ALT, alanine transaminase; AST, aspartate aminotransferase; CK, creatine kinase; CK-MB, creatine kinase isoenzymes; EM, extensive metabolizers; Hb, hemoglobin; HbAlc, glycated hemoglobin; HDL-C, high-density lipoprotein cholesterol; hs-CRP, hyper-sensitive C-reactive protein; IM, intermediate metabolizers; LDL-C, low-density lipoprotein cholesterol; NT-proBNP, N-terminal (NT)-pro hormone BNP; PM, poor metabolizers; TNT-HS, high sensitive troponin T