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Table 1 Baseline characteristics of patients with sustained, intermittent and non-PPI users

From: Intermittent concurrent use of clopidogrel and proton pump inhibitors did not increase risk of adverse clinical outcomes in Chinese patients with coronary artery disease

 

Sustained PPI users

Intermittent PPI users

Non-PPI users

p value

N

201

188

249

 

Demographic data

    

 Age (y)

66.9 ± 11.1

64.4 ± 11.4

65.2 ± 10.7

0.080

 Male (n, %)

123 (61.2%)

116 (61.7%)

174 (69.9%)

0.093

 BMI (kg/m2)

23.75 ± 4.30

24.17 ± 3.86

24.76 ± 2.97

0.022

 SBP (mmHg)

132.9 ± 20.8

134.8 ± 23.3

136.7 ± 21.1

0.180

 DBP (mmHg)

75.4 ± 12.4

77.1 ± 13.3

76.5 ± 12.3

0.408

Smoking

   

0.880

 Current

58 (28.9%)

60 (31.9%)

71 (28.5%)

 

 Former

31 (15.4%)

24 (12.8%)

39 (15.7%)

 

 None

112 (55.7%)

104 (55.3%)

139 (55.8%)

 

Alcohol

   

0.037

 Current

16 (8.0%)

15 (8.0%)

7 (2.8%)

 

 Former

5 (2.5%)

10 (5.3%)

15 (6.0%)

 

 None

180 (89.6%)

163 (86.7%)

227 (91.2%)

 

Comorbidity

    

 CHD

82 (40.8%)

57 (30.3%)

94 (37.8%)

0.088

 MI

35 (17.4%)

16 (8.5%)

35 (14.1%)

0.035

 CHF

10 (5.0%)

10 (5.3%)

11 (4.4%)

0.906

 CHD family history

26 (12.9%)

15 (8.0%)

22 (8.8%)

0.204

 Hypertension

144 (71.6%)

128 (68.1%)

179 (71.9%)

0.645

 Hypercholesterolemia

39 (19.4%)

34 (18.1%)

53 (21.3%)

0.700

 Atrial fibrosis

15 (7.5%)

11 (5.9%)

7 (2.8%)

0.076

 TIA

1 (0.5%)

2 (1.1%)

1 (0.4%)

0.659

 Stroke

34 (16.9%)

19 (10.1%)

47 (18.9%)

0.037

 DM

43 (21.4%)

61 (32.4%)

80 (32.1%)

0.019

 CKD

12 (6.0%)

17 (9.0%)

16 (6.4%)

0.440

 Gastroduodenal ulcer

45 (22.4%)

28 (14.9%)

20 (8.0%)

 < 0.001

 GI bleeding

4 (2.0%)

2 (1.1%)

4 (1.6%)

0.762

Surgical history

    

 PCI

50 (24.9%)

39 (20.7%)

70 (28.1%)

0.211

 CABG

0 (0.0%)

1 (0.5%)

2 (0.8%)

0.460

 Device implantation

6 (3.0%)

0 (0.0%)

7 (2.8%)

0.062

 Other surgical history

32 (15.9%)

30 (16.0%)

45 (18.1%)

0.781

  1. BMI, body mass index; CABG, coronary artery bypass graft; CHD, coronary heart disease; CHF, chronic heart failure; CKD, chronic kidney disease; DBP, diastolic blood pressure; DM, diabetes mellitus; GI, gastrointestinal; MI, myocardial infarction; PCI, percutaneous coronary intervention; PPI, proton pump inhibitor; SBP, systolic blood pressure; TIA, transient ischemic attack