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Table 1 Baseline characteristics of patients with sustained, intermittent and non-PPI users

From: Intermittent concurrent use of clopidogrel and proton pump inhibitors did not increase risk of adverse clinical outcomes in Chinese patients with coronary artery disease

  Sustained PPI users Intermittent PPI users Non-PPI users p value
N 201 188 249  
Demographic data     
 Age (y) 66.9 ± 11.1 64.4 ± 11.4 65.2 ± 10.7 0.080
 Male (n, %) 123 (61.2%) 116 (61.7%) 174 (69.9%) 0.093
 BMI (kg/m2) 23.75 ± 4.30 24.17 ± 3.86 24.76 ± 2.97 0.022
 SBP (mmHg) 132.9 ± 20.8 134.8 ± 23.3 136.7 ± 21.1 0.180
 DBP (mmHg) 75.4 ± 12.4 77.1 ± 13.3 76.5 ± 12.3 0.408
Smoking     0.880
 Current 58 (28.9%) 60 (31.9%) 71 (28.5%)  
 Former 31 (15.4%) 24 (12.8%) 39 (15.7%)  
 None 112 (55.7%) 104 (55.3%) 139 (55.8%)  
Alcohol     0.037
 Current 16 (8.0%) 15 (8.0%) 7 (2.8%)  
 Former 5 (2.5%) 10 (5.3%) 15 (6.0%)  
 None 180 (89.6%) 163 (86.7%) 227 (91.2%)  
Comorbidity     
 CHD 82 (40.8%) 57 (30.3%) 94 (37.8%) 0.088
 MI 35 (17.4%) 16 (8.5%) 35 (14.1%) 0.035
 CHF 10 (5.0%) 10 (5.3%) 11 (4.4%) 0.906
 CHD family history 26 (12.9%) 15 (8.0%) 22 (8.8%) 0.204
 Hypertension 144 (71.6%) 128 (68.1%) 179 (71.9%) 0.645
 Hypercholesterolemia 39 (19.4%) 34 (18.1%) 53 (21.3%) 0.700
 Atrial fibrosis 15 (7.5%) 11 (5.9%) 7 (2.8%) 0.076
 TIA 1 (0.5%) 2 (1.1%) 1 (0.4%) 0.659
 Stroke 34 (16.9%) 19 (10.1%) 47 (18.9%) 0.037
 DM 43 (21.4%) 61 (32.4%) 80 (32.1%) 0.019
 CKD 12 (6.0%) 17 (9.0%) 16 (6.4%) 0.440
 Gastroduodenal ulcer 45 (22.4%) 28 (14.9%) 20 (8.0%)  < 0.001
 GI bleeding 4 (2.0%) 2 (1.1%) 4 (1.6%) 0.762
Surgical history     
 PCI 50 (24.9%) 39 (20.7%) 70 (28.1%) 0.211
 CABG 0 (0.0%) 1 (0.5%) 2 (0.8%) 0.460
 Device implantation 6 (3.0%) 0 (0.0%) 7 (2.8%) 0.062
 Other surgical history 32 (15.9%) 30 (16.0%) 45 (18.1%) 0.781
  1. BMI, body mass index; CABG, coronary artery bypass graft; CHD, coronary heart disease; CHF, chronic heart failure; CKD, chronic kidney disease; DBP, diastolic blood pressure; DM, diabetes mellitus; GI, gastrointestinal; MI, myocardial infarction; PCI, percutaneous coronary intervention; PPI, proton pump inhibitor; SBP, systolic blood pressure; TIA, transient ischemic attack