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Table 1 Baseline clinical characteristics of study participants

From: Associations between hyperhomocysteinemia and the presence and severity of acute coronary syndrome in young adults ≤ 35 years of age

Characteristics

ACS (n = 828)

Non-CAD (n = 275)

P

Age (years)

33 (30–34)

32 (30–34)

0.206

Male, n (%)

795 (96.01)

245 (89.09)

< 0.001

SBP (mmHg)

126.04 ± 16.01

125.69 ± 14.66

0.64

DBP (mmHg)

77.71 ± 13.26

76.95 ± 11.48

0.297

HR (bpm)

75.73 ± 11.94

73.45 ± 12.09

0.004

Drinker, n (%)

148 (17.87)

56 (20.36)

0.361

Medical history and coronary risk factors

   

Smoker, n (%)

572 (69.08)

139 (50.55)

< 0.001

BMI (kg/m2)

28.52 ± 4.64

26.80 ± 4.75

< 0.001

Hypertension, n (%)

402 (48.55)

92 (33.45)

< 0.001

Diabetes mellitus, n (%)

162 (19.57)

21 (7.64)

< 0.001

Hypertriglyceridemia, n (%)

468 (56.52)

89 (32.36)

< 0.001

Hypercholesterolemia, n (%)

257 (31.04)

52 (18.91)

< 0.001

High LDL-C, n (%)

237 (28.62)

44 (16.00)

< 0.001

Low HDL-C, n (%)

580 (70.05)

138 (50.18)

 < 0.001

Family history of CAD, n (%)

116 (14.01)

24 (8.73)

0.023

Familial hypercholesterolemia, n (%)

25 (3.02)

1 (0.36)

0.01

Hyperuricemia, n (%)

367 (44.32)

97 (35.27)

0.008

Hyperhomocysteinemia, n (%)

514 (62.08)

72 (26.18)

< 0.001

Prior stroke, n (%)

4 (0.48)

0 (0.00)

0.577

Laboratory results

   

BUN (mmol/L)

4.94 ± 1.39

4.79 ± 1.34

0.1

CR (µmol/L)

74.68 ± 15.14

74.69 ± 14.08

0.988

eGFR (mL/min/1.73 m2)

106.30 (92.80, 120.60)

103.40 (93.60, 116.20)

0.064

FBG (mmol/L)

5.35 (4.91–6.43)

5.04 (4.79–5.60)

< 0.001

HbA1c (%)

5.6 (5.2–6.2)

5.4 (5.1–5.7)

< 0.001

TG (mmol/L)

1.88 (1.31–2.89)

1.45 (1.01–2.18)

< 0.001

TC (mmol/L)

4.72 ± 1.78

4.34 ± 1.03

< 0.001

HDL-C (mmol/L)

0.91 ± 0.21

1.02 ± 0.22

< 0.001

LDL-C (mmol/L)

3.01 ± 1.61

2.65 ± 0.98

< 0.001

UA (µmol/L)

410.19 ± 96.67

385.83 ± 93.82

< 0.001

HCY (µmol/L)

16.55 (11.93–29.68)

12.50 (9.71–17.42)

< 0.001

hs CRP (mg/L)

3.11 (1.09–11.40)

1.12 (0.49–2.80)

< 0.001

Cardiac function

   

LVEF

60 (54–65)

66 (62–68)

< 0.001

  1. Data are expressed as mean ± standard deviation, medians with interquartile range or number (%)
  2. CAD coronary artery disease, ACS acute coronary syndrome, SBP systolic blood pressure, DBP diastolic blood pressure, HR heart rate, BMI body mass index, BUN blood urea nitrogen, CR creatinine, eGFR estimated glomerular filtration rate, FBG fasting blood glucose, HbA1c glycosylated hemoglobin, TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, UA uric acid, HCY homocysteine, hs CRP high-sensitivity C-reactive protein, LVEF left ventricular ejection fraction
  3. Bold values indicate statistical significance
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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