Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA)

Table 4 Stratification by anti-hypertensive medication use of the immune cell subsets with a statistically significant main effect to test for effect measure modification

Immune cell subset	∆ mmHG (per SD)	95% CI		p value
Any antihypertensive medication use (median SBP 131 mmHG) n = 1852 repeated SBP measures
CD3⁺ γδ⁺	5.10	3.03	7.17	< .0001
CD3⁻ CD56⁺ CD16⁺	2.25	1.06	3.45	0.0002
CD14⁺⁺ CD16⁻	− 2.02	− 3.61	− 0.43	0.0127
CD14⁺ CD16⁺	1.16	− 0.41	2.74	0.1475
CD14_DimCD16⁺⁺	1.52	0.019	3.30	0.0472
No antihypertensive medication use (median SBP 119.5 mmHG) n = 1928 repeated SBP measures
CD3⁺ γδ⁺	1.33	0.22	2.45	0.0194
CD3⁻ CD56⁺ CD16⁺	0.76	− 0.67	2.19	0.2997
CD14⁺⁺ CD16⁻	− 0.79	− 2.22	0.63	0.2756
CD14⁺ CD16⁺	− 0.38	− 1.76	1.00	0.5912
CD14_DimCD16⁺⁺	1.56	− 0.027	3.15	0.0540

Numbers refer to blood pressure readings under treatment, as each participant may contribute multiple measures and may change antihypertensive medication exposure category over follow-up. ∆ mmHG (per SD) refers to a change in the average level of SBP over 10 years of follow-up

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