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Table 4 Stratification by anti-hypertensive medication use of the immune cell subsets with a statistically significant main effect to test for effect measure modification

From: Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA)

Immune cell subset ∆ mmHG (per SD) 95% CI p value
Any antihypertensive medication use (median SBP 131 mmHG) n = 1852 repeated SBP measures
 CD3+ γδ+ 5.10 3.03 7.17  < .0001
 CD3 CD56+ CD16+ 2.25 1.06 3.45 0.0002
 CD14++ CD16 − 2.02 − 3.61 − 0.43 0.0127
 CD14+ CD16+ 1.16 − 0.41 2.74 0.1475
 CD14DimCD16++ 1.52 0.019 3.30 0.0472
No antihypertensive medication use (median SBP 119.5 mmHG) n = 1928 repeated SBP measures
 CD3+ γδ+ 1.33 0.22 2.45 0.0194
 CD3 CD56+ CD16+ 0.76 − 0.67 2.19 0.2997
 CD14++ CD16 − 0.79 − 2.22 0.63 0.2756
 CD14+ CD16+ − 0.38 − 1.76 1.00 0.5912
 CD14DimCD16++ 1.56 − 0.027 3.15 0.0540
  1. Numbers refer to blood pressure readings under treatment, as each participant may contribute multiple measures and may change antihypertensive medication exposure category over follow-up. ∆ mmHG (per SD) refers to a change in the average level of SBP over 10 years of follow-up