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Table 3 Associations between lymphocyte subsets (per 1-SD) and average systolic blood pressure level (mmHG) across 10 years of follow-up

From: Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA)

 

∆ mmHG (per SD)

95% CI lower

95% CI upper

p value

Primary hypotheses (significance threshold p < 0.0125)

 Th1

1.19

− 0.41

2.79

0.15

 Th17

− 0.06

− 1.31

1.18

0.92

 Tregs

1.09

0.05

2.13

0.04

 γδ T

2.40

1.34

3.42

< 0.0001

Exploratory hypotheses (significance threshold p < 0.0017)

 T cells

− 1.22

− 2.34

− 0.09

0.03

 B cells

− 0.45

− 1.6

0.7

0.44

 NK cells

1.88

0.82

2.94

0.0005

 Classical monocytes

− 2.01

− 3.24

− 0.79

0.0013

 Intermediate monocytes

0.98

− 0.31

2.28

0.14

 Non-classical monocytes

1.82

0.64

3.00

0.0025

 CD4+

− 0.15

− 1.19

0.89

0.78

 Th2

− 0.14

− 1.45

1.18

0.84

 Naïve CD4+

0.18

− 0.97

1.34

0.76

 Memory CD4+

0.49

− 0.68

1.65

0.41

 CD4+ CD28

− 0.19

− 1.34

0.96

0.75

 CD4+ CD28 CD57+

− 0.04

− 1.17

1.08

0.94

 CD4+ TEMRA

0.45

− 0.53

1.43

0.37

 CD4+ CD38+

− 0.36

− 1.51

0.80

0.54

 CD4+ CD57+

0.05

− 1.07

1.17

0.93

 CD8+

0.11

− 1.02

1.24

0.85

 Tc1

1.24

− 0.11

2.59

0.07

 Tc2

− 0.93

− 2.21

0.34

0.15

 Tc17

0.49

− 0.90

1.88

0.49

 Naïve CD8+

0.97

− 0.15

2.09

0.09

 Memory CD8+

− 1.02

− 2.13

0.09

0.07

 CD8+ CD28

0.91

− 0.28

2.09

0.13

 CD8+ CD28 CD57+

0.69

− 0.46

1.84

0.24

 CD8+ TEMRA

0.99

− 0.13

2.12

0.08

 CD8+ CD38+

0.53

− 0.58

1.64

0.35

 CD8+ CD57+

0.42

− 0.67

1.52

0.45

  1. Statistical models are linear mixed models using repeated blood pressure measures for MESA exams 1–5, and adjusted for baseline age, sex, race/ethnicity, smoking, exercise, body mass index, college education, diabetes, and log transformed CMV antibody titer