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Table 3 Associations between lymphocyte subsets (per 1-SD) and average systolic blood pressure level (mmHG) across 10 years of follow-up

From: Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA)

  ∆ mmHG (per SD) 95% CI lower 95% CI upper p value
Primary hypotheses (significance threshold p < 0.0125)
 Th1 1.19 − 0.41 2.79 0.15
 Th17 − 0.06 − 1.31 1.18 0.92
 Tregs 1.09 0.05 2.13 0.04
 γδ T 2.40 1.34 3.42 < 0.0001
Exploratory hypotheses (significance threshold p < 0.0017)
 T cells − 1.22 − 2.34 − 0.09 0.03
 B cells − 0.45 − 1.6 0.7 0.44
 NK cells 1.88 0.82 2.94 0.0005
 Classical monocytes − 2.01 − 3.24 − 0.79 0.0013
 Intermediate monocytes 0.98 − 0.31 2.28 0.14
 Non-classical monocytes 1.82 0.64 3.00 0.0025
 CD4+ − 0.15 − 1.19 0.89 0.78
 Th2 − 0.14 − 1.45 1.18 0.84
 Naïve CD4+ 0.18 − 0.97 1.34 0.76
 Memory CD4+ 0.49 − 0.68 1.65 0.41
 CD4+ CD28 − 0.19 − 1.34 0.96 0.75
 CD4+ CD28 CD57+ − 0.04 − 1.17 1.08 0.94
 CD4+ TEMRA 0.45 − 0.53 1.43 0.37
 CD4+ CD38+ − 0.36 − 1.51 0.80 0.54
 CD4+ CD57+ 0.05 − 1.07 1.17 0.93
 CD8+ 0.11 − 1.02 1.24 0.85
 Tc1 1.24 − 0.11 2.59 0.07
 Tc2 − 0.93 − 2.21 0.34 0.15
 Tc17 0.49 − 0.90 1.88 0.49
 Naïve CD8+ 0.97 − 0.15 2.09 0.09
 Memory CD8+ − 1.02 − 2.13 0.09 0.07
 CD8+ CD28 0.91 − 0.28 2.09 0.13
 CD8+ CD28 CD57+ 0.69 − 0.46 1.84 0.24
 CD8+ TEMRA 0.99 − 0.13 2.12 0.08
 CD8+ CD38+ 0.53 − 0.58 1.64 0.35
 CD8+ CD57+ 0.42 − 0.67 1.52 0.45
  1. Statistical models are linear mixed models using repeated blood pressure measures for MESA exams 1–5, and adjusted for baseline age, sex, race/ethnicity, smoking, exercise, body mass index, college education, diabetes, and log transformed CMV antibody titer