Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA)

Delaney, Joseph A. C.; Olson, Nels C.; Sitlani, Colleen M.; Fohner, Alison E.; Huber, Sally A.; Landay, Alan L.; Heckbert, Susan R.; Tracy, Russell P.; Psaty, Bruce M.; Feinstein, Matt; Doyle, Margaret F.

doi:10.1186/s12872-021-01857-2

Table 2 Cellular phenotypes with their molecular description, parent population, number of samples evaluated, means and standard deviations

From: Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA)

Cellular phenotype	Molecular description	Parent population	N	Mean	SD
Primary hypotheses
Th1	CD4⁺ IFN-γ⁺	CD4⁺	770	15.3	9.0
Th17	CD4⁺ IL-17A⁺	CD4⁺	770	2.1	1.4
Tregs	CD4⁺ CD25⁺ CD127⁻	CD4⁺	1113	6.2	3.8
γδ T cells	CD3⁺ γδ⁺	CD3⁺	1087	6.6	6.1
Exploratory hypotheses
T cells	CD3⁺	% Lymphocytes	1087	62.7	13.7
B cells	CD19⁺	% Lymphocytes	1087	11.3	7.4
NK cells	CD3⁻ CD56⁺ CD16⁺	% Lymphocytes	1087	5.0	5.7
Classical monocytes	CD14⁺⁺ CD16⁻	CD14 total	922	74.4	10.2
Intermediate monocytes	CD14⁺ CD16⁺	CD14 total	922	18.1	7.1
Non-classical monocytes	CD14_DimCD16⁺	CD14 total	922	7.4	7.5
T helper cells	CD4⁺	% Lymphocytes	1051	50.0	11.0
Th2 cells	CD4⁺ IL-4⁺	CD4⁺	770	2.9	1.8
Naive CD4⁺ cells	CD4⁺ CD45RA⁺	CD4⁺	1051	26.2	12.1
Memory CD4⁺ cells	CD4⁺ CD45RO⁺	CD4⁺	1051	51.7	13.4
CD28-senescent CD4 cells	CD4⁺ CD28⁻	CD4⁺	1051	13.9	10.0
CD28-CD57⁺ senescent CD4 cells	CD4⁺ CD28⁻ CD57⁺	CD4⁺	1051	9.9	8.5
CD4⁺ T_EMRA	CD4⁺ CD45RA⁺ CD28⁻ CD57⁺	CD4⁺	1051	5.6	5.3
Activated/mature CD4⁺ cells	CD4⁺ CD38⁺	CD4⁺	1051	26.1	12.1
CD57⁺ CD4⁺ cells	CD4⁺ CD57⁺	CD4⁺	1051	22.4	13.0
Cytotoxic T cells	CD8⁺	% Lymphocytes	1062	23.6	9.3
Tc1	CD8⁺ IFN-γ⁺	CD8⁺	770	41.8	17.9
Tc2	CD8⁺ IL-4⁺	CD8⁺	770	7.1	4.9
Tc17	CD8⁺ IL-17A⁺	CD8⁺	770	5.4	5.8
Naive CD8⁺ cells	CD8⁺ CD45RA⁺	CD8⁺	1062	52.4	14.7
Memory CD8⁺ cells	CD8⁺ CD45RO⁺	CD8⁺	1062	21.7	10.6
CD28-senescent CD8 cells	CD8⁺ CD28⁻	CD8⁺	1062	55.6	15.9
CD28⁻ CD57⁺ senescent CD8 cells	CD8⁺ CD28⁻ CD57⁺	CD8⁺	1062	44.5	15.9
CD8⁺ T_EMRA	CD8⁺ CD45RA⁺ CD28⁻ CD57⁺	CD8⁺	1062	32.8	14.3
Activated/mature CD8⁺ cells	CD8⁺ CD38⁺	CD8⁺	1062	23.6	12.2
CD57⁺ CD8⁺ cells	CD8⁺ CD57⁺	CD8⁺	1062	59.3	15.4

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ISSN: 1471-2261

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