|
A. Individual variables (w/o risk scores)
|
|---|
|
Variables
|
Univariate Cox analysis
|
Multivariate Cox analysis
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|---|
|
HR (95% CI)
|
P value
|
HR (95% CI)
|
P value
|
|---|
|
Age
|
1.04 (1.01–1.06)
|
0.004
|
1.03 (1.00–1.05)
|
0.023
|
|
BMI
|
0.93 (0.87–0.99)
|
0.030
|
ns‡
|
|
eGFR
|
0.99 (0.98–1.00)
|
0.009
|
ns‡
|
|
Female gender
|
1.86 (1.12–3.09)
|
0.016
|
1.67 (1.00–2.79)
|
0.051
|
|
Atrial fibrillation
|
2.24 (1.17–4.29)
|
0.015
|
2.02 (1.04–3.89)
|
0.037
|
|
Previous MI
|
1.75 (0.92–3.35)
|
0.091
|
ns‡
|
|
Conservative treatment vs. revascularization
|
1.53 (0.90–2.60)
|
0.114
|
n/a§
|
|
B. Risk scores
|
|---|
|
Variables
|
Univariate Cox analysis
|
Multivariate Cox analysis
|
|---|
|
HR (95% CI)
|
P value
|
HR (95% CI)
|
P value
|
|---|
|
GRACE
|
1.01 (1.00–1.02)*
|
0.088
|
0.97 (0.86–1.10)‖
|
0.664
|
|
1.09 (0.99–1.19)†
|
0.076
|
|
ACEF
|
2.16 (1.36–3.44)*
|
0.001
|
2.16 (1.36–3.44)¶
|
0.001
|
|
SYNTAX
|
1.00 (0.98–1.03)*
|
0.880
|
n/a§
|
|
0.99 (0.79–1.25)†
|
0.948
|
|
Clinical SYNTAX
|
1.01 (1.00–1.03)*
|
0.063
|
n/a§
|
|
1.14 (0.99–1.29)†
|
0.059
|
|
SYNTAX II PCI
|
1.04 (1.01–1.06)*
|
0.001
|
1.22 (0.88–1.69)‖
|
0.237
|
|
1.37 (1.11–1.79)†
|
0.004
|
|
SYNTAX II CABG
|
1.02 (1.00–1.04)*
|
0.040
|
n/a§
|
|
1.22 (1.00–1.50)†
|
0.053
|
- ACEF—age, creatinine and ejection fraction risk score; BMI—body mass index; CABG—coronary artery bypass graft; eGFR—estimated glomerular filtration rate; GRACE—Global Registry of Acute coronary events risk score; LVEF—left ventricular ejecton fraction; MACE—major adverse cardiovascular events; MI—myocardial infarction; PCI—percutaneous coronary intervention; SYNTAX—The Synergy Between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery risk score
- *HR value corresponds to each 1 unit increase/decrease of each score
- †HR value corresponds to each 10 unit increase/decrease of each score
- ‡ns indicates variables which were not held in the model due to statistical insignificance (stepwise forward algorithm)
- §n/a indicates variables which were a priori not included in the multivariate analysis due to P > 0.1 and/or multicollinearity
- ‖The intermediate step of the multivariate analysis (stepwise forward algorithm)
- ¶The final step of the multivariate analysis (stepwise forward algorithm)
