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Table 3 Predictors of MACE

From: ACEF performed better than other risk scores in non-ST-elevation acute coronary syndrome during long term follow-up

A. Individual variables (w/o risk scores)
Variables Univariate Cox analysis Multivariate Cox analysis
HR (95% CI) P value HR (95% CI) P value
Age 1.04 (1.01–1.06) 0.004 1.03 (1.00–1.05) 0.023
BMI 0.93 (0.87–0.99) 0.030 ns
eGFR 0.99 (0.98–1.00) 0.009 ns
Female gender 1.86 (1.12–3.09) 0.016 1.67 (1.00–2.79) 0.051
Atrial fibrillation 2.24 (1.17–4.29) 0.015 2.02 (1.04–3.89) 0.037
Previous MI 1.75 (0.92–3.35) 0.091 ns
Conservative treatment vs. revascularization 1.53 (0.90–2.60) 0.114 n/a§
B. Risk scores
Variables Univariate Cox analysis Multivariate Cox analysis
HR (95% CI) P value HR (95% CI) P value
GRACE 1.01 (1.00–1.02)* 0.088 0.97 (0.86–1.10) 0.664
1.09 (0.99–1.19) 0.076
ACEF 2.16 (1.36–3.44)* 0.001 2.16 (1.36–3.44) 0.001
SYNTAX 1.00 (0.98–1.03)* 0.880 n/a§
0.99 (0.79–1.25) 0.948
Clinical SYNTAX 1.01 (1.00–1.03)* 0.063 n/a§
1.14 (0.99–1.29) 0.059
SYNTAX II PCI 1.04 (1.01–1.06)* 0.001 1.22 (0.88–1.69) 0.237
1.37 (1.11–1.79) 0.004
SYNTAX II CABG 1.02 (1.00–1.04)* 0.040 n/a§
1.22 (1.00–1.50) 0.053
  1. ACEF—age, creatinine and ejection fraction risk score; BMI—body mass index; CABG—coronary artery bypass graft; eGFR—estimated glomerular filtration rate; GRACE—Global Registry of Acute coronary events risk score; LVEF—left ventricular ejecton fraction; MACE—major adverse cardiovascular events; MI—myocardial infarction; PCI—percutaneous coronary intervention; SYNTAX—The Synergy Between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery risk score
  2. *HR value corresponds to each 1 unit increase/decrease of each score
  3. HR value corresponds to each 10 unit increase/decrease of each score
  4. ns indicates variables which were not held in the model due to statistical insignificance (stepwise forward algorithm)
  5. §n/a indicates variables which were a priori not included in the multivariate analysis due to P > 0.1 and/or multicollinearity
  6. The intermediate step of the multivariate analysis (stepwise forward algorithm)
  7. The final step of the multivariate analysis (stepwise forward algorithm)