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Table 4 Factors correlated with 2-year ISR

From: FGF-23 correlates with endocrine and metabolism dysregulation, worse cardiac and renal function, inflammation level, stenosis degree, and independently predicts in-stent restenosis risk in coronary heart disease patients underwent drug-eluting-stent PCI

Items

Logistic regression model

P value

OR

95% CI

Lower

Higher

Univariate logistic regression

FGF-23

< 0.001

1.006

1.004

1.008

Age

0.199

1.026

0.987

1.067

Male

0.163

2.186

0.728

6.559

BMI

0.460

1.036

0.943

1.139

Current smoke

0.362

1.428

0.664

3.070

Hypertension

0.094

2.121

0.881

5.108

Diabetes mellitus

0.001

3.437

1.667

7.086

Hypercholesteremia

0.012

3.066

1.280

7.344

Hyperuricemia

0.009

2.579

1.263

5.264

Family history of CAD

0.099

1.928

0.884

4.204

MAP

0.498

1.007

0.987

1.027

FBG

0.020

1.429

1.058

1.930

IRI

0.002

1.391

1.127

1.716

Scr

0.020

1.027

1.004

1.051

SUA

0.241

1.003

0.998

1.007

TG

0.625

1.103

0.745

1.634

TC

0.060

1.426

0.985

2.064

LDL-C

0.002

2.551

1.394

4.666

HDL-C

0.026

0.170

0.036

0.812

HsCRP

< 0.001

1.195

1.099

1.299

ESR

0.180

1.025

0.989

1.063

WBC

0.469

1.085

0.870

1.355

Neutrophil

0.303

1.199

0.848

1.695

LVEF

0.404

0.978

0.927

1.031

cTnI

0.129

1.013

0.996

1.030

NT-proBNP

0.080

1.005

0.999

1.010

Multivessel artery lesion

0.010

14.276

1.906

106.910

Patients with two target lesions

0.008

2.647

1.296

5.405

Target lesion at LAD

0.643

1.187

0.575

2.449

Target lesion at LCX

0.020

2.329

1.144

4.741

Target lesion at RCA

0.888

0.949

0.459

1.961

Stenosis degree of target lesion

0.098

1.071

0.988

1.161

Length of target lesion

0.009

1.054

1.013

1.097

Length of stent

0.010

1.053

1.012

1.095

Diameter of stent

0.488

0.692

0.244

1.959

Time of stent dilation

0.942

1.003

0.920

1.094

Pre-stent balloon dilation

0.506

0.765

0.348

1.684

β-receptor blockers

0.249

0.592

0.243

1.443

ACEIs/ARBs

0.035

0.466

0.229

0.946

Calcium channel blockers

0.427

0.727

0.331

1.597

Multivariate logistic regression (forward stepwise: conditional)

FGF-23

0.001

1.005

1.002

1.007

Diabetes mellitus

< 0.001

23.654

6.374

87.782

LDL-C

0.002

4.458

1.759

11.294

HsCRP

< 0.001

1.261

1.117

1.424

Patients with two target lesions

0.002

6.305

2.015

19.728

Length of target lesion

0.001

1.128

1.054

1.208

  1. Boldface represented P < 0.05. Factors with P < 0.05 in the univariate logistic regression were further analyzed by multivariate logistic regression with forward stepwise (conditional) method
  2. ISR in-stent restenosis, OR odds ratio, CI confidence interval, FGF-23 fibroblast growth factor 23, BMI body mass index, CAD coronary artery disease, MAP mean arterial pressure, FBG fasting blood-glucose, IRI insulin resistance index, Scr serum creatinine, SUA serum uric acid, TG triglyceride, TC total cholesterol, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol, HsCRP high-sensitivity C-reactive protein, ESR erythrocyte sedimentation rate, WBC white blood cell, LVEF left ventricular ejection fraction, cTnI cardiac troponin I, NT-proBNP N-terminal-proB-type natriuretic peptide, LAD left anterior descending branch, LCX left circumflex artery, RCA right coronary artery, ACEIs angiotensin converting enzymes inhibitors, ARBs angiotensin receptor blockers
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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