Skip to main content

Table 4 Factors correlated with 2-year ISR

From: FGF-23 correlates with endocrine and metabolism dysregulation, worse cardiac and renal function, inflammation level, stenosis degree, and independently predicts in-stent restenosis risk in coronary heart disease patients underwent drug-eluting-stent PCI

Items Logistic regression model
P value OR 95% CI
Lower Higher
Univariate logistic regression
FGF-23 < 0.001 1.006 1.004 1.008
Age 0.199 1.026 0.987 1.067
Male 0.163 2.186 0.728 6.559
BMI 0.460 1.036 0.943 1.139
Current smoke 0.362 1.428 0.664 3.070
Hypertension 0.094 2.121 0.881 5.108
Diabetes mellitus 0.001 3.437 1.667 7.086
Hypercholesteremia 0.012 3.066 1.280 7.344
Hyperuricemia 0.009 2.579 1.263 5.264
Family history of CAD 0.099 1.928 0.884 4.204
MAP 0.498 1.007 0.987 1.027
FBG 0.020 1.429 1.058 1.930
IRI 0.002 1.391 1.127 1.716
Scr 0.020 1.027 1.004 1.051
SUA 0.241 1.003 0.998 1.007
TG 0.625 1.103 0.745 1.634
TC 0.060 1.426 0.985 2.064
LDL-C 0.002 2.551 1.394 4.666
HDL-C 0.026 0.170 0.036 0.812
HsCRP < 0.001 1.195 1.099 1.299
ESR 0.180 1.025 0.989 1.063
WBC 0.469 1.085 0.870 1.355
Neutrophil 0.303 1.199 0.848 1.695
LVEF 0.404 0.978 0.927 1.031
cTnI 0.129 1.013 0.996 1.030
NT-proBNP 0.080 1.005 0.999 1.010
Multivessel artery lesion 0.010 14.276 1.906 106.910
Patients with two target lesions 0.008 2.647 1.296 5.405
Target lesion at LAD 0.643 1.187 0.575 2.449
Target lesion at LCX 0.020 2.329 1.144 4.741
Target lesion at RCA 0.888 0.949 0.459 1.961
Stenosis degree of target lesion 0.098 1.071 0.988 1.161
Length of target lesion 0.009 1.054 1.013 1.097
Length of stent 0.010 1.053 1.012 1.095
Diameter of stent 0.488 0.692 0.244 1.959
Time of stent dilation 0.942 1.003 0.920 1.094
Pre-stent balloon dilation 0.506 0.765 0.348 1.684
β-receptor blockers 0.249 0.592 0.243 1.443
ACEIs/ARBs 0.035 0.466 0.229 0.946
Calcium channel blockers 0.427 0.727 0.331 1.597
Multivariate logistic regression (forward stepwise: conditional)
FGF-23 0.001 1.005 1.002 1.007
Diabetes mellitus < 0.001 23.654 6.374 87.782
LDL-C 0.002 4.458 1.759 11.294
HsCRP < 0.001 1.261 1.117 1.424
Patients with two target lesions 0.002 6.305 2.015 19.728
Length of target lesion 0.001 1.128 1.054 1.208
  1. Boldface represented P < 0.05. Factors with P < 0.05 in the univariate logistic regression were further analyzed by multivariate logistic regression with forward stepwise (conditional) method
  2. ISR in-stent restenosis, OR odds ratio, CI confidence interval, FGF-23 fibroblast growth factor 23, BMI body mass index, CAD coronary artery disease, MAP mean arterial pressure, FBG fasting blood-glucose, IRI insulin resistance index, Scr serum creatinine, SUA serum uric acid, TG triglyceride, TC total cholesterol, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol, HsCRP high-sensitivity C-reactive protein, ESR erythrocyte sedimentation rate, WBC white blood cell, LVEF left ventricular ejection fraction, cTnI cardiac troponin I, NT-proBNP N-terminal-proB-type natriuretic peptide, LAD left anterior descending branch, LCX left circumflex artery, RCA right coronary artery, ACEIs angiotensin converting enzymes inhibitors, ARBs angiotensin receptor blockers