Table 2 Three functional description terms with best-scoring p-value of each MCODE identified network
Network | Annotations #1 | Annotations #2 | Annotations #3 | |||
|---|---|---|---|---|---|---|
MCODE ALL | GO:0007204 | positive regulation of cytosolic calcium ion concentration | GO:0046649 | lymphocyte activation | GO:0051480 | regulation of cytosolic calcium ion concentration |
MCODE 1 | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | R-HSA-418594 | G alpha (i) signalling events | R-HSA-500792 | GPCR ligand binding |
MCODE 2 | hsa04660 | T cell receptor signaling pathway | M88 | PID CD8 TCR PATHWAY | M272 | PID CD8 TCR DOWNSTREAM PATHWAY |
MCODE 4 | R-HSA-445355 | Smooth Muscle Contraction | R-HSA-397014 | Muscle contraction | GO:0006936 | muscle contraction |
MCODE 5 | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | GO:0050853 | B cell receptor signaling pathway |
MCODE 6 | hsa04064 | NF-kappa B signaling pathway | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
MCODE 7 | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | R-HSA-9664407 | Parasite infection |
MCODE 8 | hsa05200 | Pathways in cancer | Â | Â | Â | Â |
MCODE 10 | R-HSA-416476 | G alpha (q) signalling events | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | R-HSA-500792 | GPCR ligand binding |