Lipid profile and prognosis in patients with coronary heart disease: a meta-analysis of prospective cohort studies

Table 2 Summary results of lipid profile values and prognosis in patients with coronary heart disease

Factors	Outcomes	References	RR and 95% CI	P value	Heterogeneity (%)	P value for heterogeneity
TC per SD increase	MACE	[36,37,38,39]	0.88 (0.67–1.17)	0.380	67.4	0.015
	All-cause mortality	[20, 37]	0.88 (0.74–1.04)	0.131	50.6	0.155
	Cardiac death	[19,20,21]	1.06 (0.98–1.16)	0.150	79.7	0.007
TC (low versus high)	MACE	[21, 29]	0.84 (0.56–1.26)	0.389	56.6	0.129
TC (low versus high)	Cardiac death	[21, 28]	0.82 (0.47–1.43)	0.486	79.2	0.028
TG per SD increase	MACE	[36, 38, 39]	0.99 (0.99–1.00)	0.004	41.4	0.163
TG (high versus low)	MACE	[21, 30, 35]	1.13 (0.96–1.33)	0.134	22.5	0.275
LDL-C per SD increase	MACE	[23, 36, 38, 39]	1.00 (0.99–1.02)	0.640	81.4	< 0.001
LDL-C (high versus low)	MACE	[21, 25, 35]	1.12 (0.80–1.55)	0.512	69.7	0.037
	All-cause mortality	[25, 31]	1.01 (0.21–4.77)	0.994	84.1	0.012
	Cardiac death	[28, 31]	2.25 (0.87–5.79)	0.093	59.6	0.116
HDL-C per SD increase	MACE	[23, 36, 38, 39]	0.86 (0.67–1.11)	0.252	76.5	0.002
	All-cause mortality	[20, 21, 29]	0.97 (0.93–1.00)	0.065	85.2	< 0.001
	Cardiac death	[20, 21, 29]	0.94 (0.89–1.00)	0.048	89.2	< 0.001
HDL-C (low versus high)	MACE	[21, 24, 27, 32, 34, 35]	1.24 (1.09–1.42)	0.002	0.0	0.462
	All-cause mortality	[26, 27, 29, 31]	1.52 (1.09–2.12)	0.014	64.0	0.025
	Cardiac death	[27,28,29, 31]	1.44 (1.11–1.87)	0.006	29.8	0.223
Lipoprotein(a) (high vs low)	MACE	[23, 33, 39]	1.47 (1.16–1.87)	0.001	0.0	0.386

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