|
Factors
|
Outcomes
|
References
|
RR and 95% CI
|
P value
|
Heterogeneity (%)
|
P value for heterogeneity
|
|---|
|
TC per SD increase
|
MACE
|
[36,37,38,39]
|
0.88 (0.67–1.17)
|
0.380
|
67.4
|
0.015
|
|
All-cause mortality
|
[20, 37]
|
0.88 (0.74–1.04)
|
0.131
|
50.6
|
0.155
|
|
Cardiac death
|
[19,20,21]
|
1.06 (0.98–1.16)
|
0.150
|
79.7
|
0.007
|
|
TC (low versus high)
|
MACE
|
[21, 29]
|
0.84 (0.56–1.26)
|
0.389
|
56.6
|
0.129
|
|
Cardiac death
|
[21, 28]
|
0.82 (0.47–1.43)
|
0.486
|
79.2
|
0.028
|
|
TG per SD increase
|
MACE
|
[36, 38, 39]
|
0.99 (0.99–1.00)
|
0.004
|
41.4
|
0.163
|
|
TG (high versus low)
|
MACE
|
[21, 30, 35]
|
1.13 (0.96–1.33)
|
0.134
|
22.5
|
0.275
|
|
LDL-C per SD increase
|
MACE
|
[23, 36, 38, 39]
|
1.00 (0.99–1.02)
|
0.640
|
81.4
|
< 0.001
|
|
LDL-C (high versus low)
|
MACE
|
[21, 25, 35]
|
1.12 (0.80–1.55)
|
0.512
|
69.7
|
0.037
|
|
All-cause mortality
|
[25, 31]
|
1.01 (0.21–4.77)
|
0.994
|
84.1
|
0.012
|
|
Cardiac death
|
[28, 31]
|
2.25 (0.87–5.79)
|
0.093
|
59.6
|
0.116
|
|
HDL-C per SD increase
|
MACE
|
[23, 36, 38, 39]
|
0.86 (0.67–1.11)
|
0.252
|
76.5
|
0.002
|
|
All-cause mortality
|
[20, 21, 29]
|
0.97 (0.93–1.00)
|
0.065
|
85.2
|
< 0.001
|
|
Cardiac death
|
[20, 21, 29]
|
0.94 (0.89–1.00)
|
0.048
|
89.2
|
< 0.001
|
|
HDL-C (low versus high)
|
MACE
|
[21, 24, 27, 32, 34, 35]
|
1.24 (1.09–1.42)
|
0.002
|
0.0
|
0.462
|
|
All-cause mortality
|
[26, 27, 29, 31]
|
1.52 (1.09–2.12)
|
0.014
|
64.0
|
0.025
|
|
Cardiac death
|
[27,28,29, 31]
|
1.44 (1.11–1.87)
|
0.006
|
29.8
|
0.223
|
|
Lipoprotein(a) (high vs low)
|
MACE
|
[23, 33, 39]
|
1.47 (1.16–1.87)
|
0.001
|
0.0
|
0.386
|
