Risk factors associated with major adverse cardiac and cerebrovascular events following percutaneous coronary intervention: a 10-year follow-up comparing random survival forest and Cox proportional-hazards model

Table 3 Cox regression analyses of factors associated with the occurrence of MACCE after angioplasty in a 10-year follow-up

Variable	Unadjusted hazard ratio	95% CI	P value	Adjusted hazard ratio	95% CI	P value
Diabetes			< 0.001			0.003
No	Reference			Reference
Yes	3.01	1.95–4.64		2.17	1.29–3.66
Smoking			0.001			< 0.001
No	Reference			Reference
Yes	2.04	1.36–3.07		2.41	1.46–3.98
Age (years)	1.03	1.02–1.05	< 0.001	1.03	1.01–1.05	< 0.001
Stent length			0.007			0.016
≤ 20 mm	Reference			Reference
> 20 mm	1.73	1.15–2.58		1.74	1.107–2.75
Setting			0.192			0.186
ACS	Reference			Reference
CSA	1.205	0.91–1.59		0.73	0.46–1.16
Hyperlipidemia			0.093			0.692
No	Reference			Reference
Yes	1.44	0.94–2.21		1.106	0.66–1.83
Number of stents			0.11
1	Reference			Reference
2	0.62	0.34–1.12	0.658	0.79	0.46–1.34	0.382
3	0.52	0.27–0.97	0.028	1.8	0.82–3.94	0.138
Sex			0.904			0.865
Female	Reference			Reference
Male	0.97	0.63–1.05		1.05	0.59–1.85
PCI			0.55			0.799
Ad hoc	Reference			Reference
Elective	1.13	0.75–1.69		0.94	0.61–1.45
Type of stent			0.75			0.166
BMS	Reference			Reference
DES	0.93	0.61–1.41		1.41	0.86–2.301
Stent diameter			0.992			0.534
3 mm	Reference			Reference
3.5 mm	0.98	0.63–1.49	0.175	0.75	0.47–1.203	0.239
4 mm	0.97	0.47–1.97	0.187	1	0.46–2.14	0.999
Number of vessels			0.208			0.344
1	Reference			Reference
2	1.19	0.75–1.87	0.451	1.39	0.84–2.31	0.198
3	1.64	0.94–2.87	0.078	1.45	0.77–2.74	0.245
Hypertension			0.031			0.526
No	Reference			Reference
Yes	1.55	1.04–2.32		1.16	0.72–1.9

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