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Table 4 Cox regression analysis for long-term mortality

From: Time to peak bilirubin concentration and advanced AKI were associated with increased mortality in rheumatic heart valve replacement surgery patients with severe postoperative hyperbilirubinemia: a retrospective cohort study

Variables

Univariate Cox regression

Multivariate Cox regression

HR (95%CI)

P value

HR (95%CI)

P value

Preoperative

    

Age

1.014 (1.011–1.073)

0.008

  

APACHE II score

1.122 (1.060–1.188)

 < 0.001

  

CKD (eGFR < 60 ml/min)

0.914 (0.511–1.636)

0.763

  

EuroSCORE II

1.325 (1.110–1.583)

0.002

  

Intraoperative

    

Operation duration

1.248 (1.098–1.414)

0.001

  

CPB time

1.005 (1.002–1.008)

0.001

  

The amount of blood transfusion

1.704 (1.037–1.112)

 < 0.001

1.051 (1.012–1.091)

0.01

Postoperative

    

SOFA score

1.356 (1.202–1.531)

 < 0.001

  

MELD score

1.086 (1.009–1.169)

0.028

  

Hb

0.981 (0.968–0.995)

0.008

  

PLT

0.991 (0.986–0.997)

0.002

  

Cr

1.009 (1.002–1.016)

0.008

  

Peak TB level

1.005 (1.003–1.008)

 < 0.001

  

Time to peak TB level

1.142 (1.089–1.198)

 < 0.001

  

AKI

5.19 (1.620–16.628)

0.006

  

 Advanced AKI

10.374 (5.606–19.199)

 < 0.001

7.379 (3.791–14.364)

 < 0.001

CRRT

5.64 (3.259–9.763)

 < 0.001

  

Use of ECMO

4.641 (2.240–9.612)

 < 0.001

  

PE/BA

2.791 (1.186–6.597)

0.019

  

Onset time of hyperbilirubinemia

1.218 (1.119–1.326)

 < 0.001

  

Duration of mechanical ventilation

1.186 (1.128–1.246)

 < 0.001

1.078 (1.017–1.143)

0.011

The total amount of blood transfusion

1.019 (1.014–1.024)

 < 0.001

  

ICU stay time

1.044 (1.019–1.070)

0.001

  
  1. AKI, acute kidney injury; APACHEII, acute physiology and chronic health evaluation II; BA, bilirubin adsorption; CPB, cardiopulmonary bypass; Cr, creatinine; CRRT, continuous renal replacement therapy; ECMO, extracorporeal membrane oxygenation; eGFR, estimated glomerular filtration rate; Hb, hemoglobin; ICU, intensive care unit; MAP, mean arterial pressure; PE, plasma exchange; PLT, platelet; SOFA, sequential organ failure assessment; TB, total bilirubin