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Table 4 Cox regression analysis for long-term mortality

From: Time to peak bilirubin concentration and advanced AKI were associated with increased mortality in rheumatic heart valve replacement surgery patients with severe postoperative hyperbilirubinemia: a retrospective cohort study

Variables Univariate Cox regression Multivariate Cox regression
HR (95%CI) P value HR (95%CI) P value
Preoperative     
Age 1.014 (1.011–1.073) 0.008   
APACHE II score 1.122 (1.060–1.188)  < 0.001   
CKD (eGFR < 60 ml/min) 0.914 (0.511–1.636) 0.763   
EuroSCORE II 1.325 (1.110–1.583) 0.002   
Intraoperative     
Operation duration 1.248 (1.098–1.414) 0.001   
CPB time 1.005 (1.002–1.008) 0.001   
The amount of blood transfusion 1.704 (1.037–1.112)  < 0.001 1.051 (1.012–1.091) 0.01
Postoperative     
SOFA score 1.356 (1.202–1.531)  < 0.001   
MELD score 1.086 (1.009–1.169) 0.028   
Hb 0.981 (0.968–0.995) 0.008   
PLT 0.991 (0.986–0.997) 0.002   
Cr 1.009 (1.002–1.016) 0.008   
Peak TB level 1.005 (1.003–1.008)  < 0.001   
Time to peak TB level 1.142 (1.089–1.198)  < 0.001   
AKI 5.19 (1.620–16.628) 0.006   
 Advanced AKI 10.374 (5.606–19.199)  < 0.001 7.379 (3.791–14.364)  < 0.001
CRRT 5.64 (3.259–9.763)  < 0.001   
Use of ECMO 4.641 (2.240–9.612)  < 0.001   
PE/BA 2.791 (1.186–6.597) 0.019   
Onset time of hyperbilirubinemia 1.218 (1.119–1.326)  < 0.001   
Duration of mechanical ventilation 1.186 (1.128–1.246)  < 0.001 1.078 (1.017–1.143) 0.011
The total amount of blood transfusion 1.019 (1.014–1.024)  < 0.001   
ICU stay time 1.044 (1.019–1.070) 0.001   
  1. AKI, acute kidney injury; APACHEII, acute physiology and chronic health evaluation II; BA, bilirubin adsorption; CPB, cardiopulmonary bypass; Cr, creatinine; CRRT, continuous renal replacement therapy; ECMO, extracorporeal membrane oxygenation; eGFR, estimated glomerular filtration rate; Hb, hemoglobin; ICU, intensive care unit; MAP, mean arterial pressure; PE, plasma exchange; PLT, platelet; SOFA, sequential organ failure assessment; TB, total bilirubin