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Table 3 Logistic regression analysis for in-hospital mortality

From: Time to peak bilirubin concentration and advanced AKI were associated with increased mortality in rheumatic heart valve replacement surgery patients with severe postoperative hyperbilirubinemia: a retrospective cohort study

Characteristic Univariate logistic regression Multivariate logistic regression (model 1) Multivariate logistic regression (model 2)
OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value
Age 1.55 (1.011–1.101) 0.014     
Preoperative       
 APACHE II score 1.194 (1.051–1.356) 0.006     
 CKD (eGFR < 60 ml/min) 1.233 (0.582–2.614) 0.584     
 EuroSCORE II 1.435 (1.103–1.867) 0.007     
Intraoperative       
 Operative time 1.570 (1.208 – 2.041) 0.001     
 CPB time 1.007 (1.001–1.013) 0.018     
 Amount of blood transfusion 1.078 (1.021 – 1.139) 0.007    1.078 (1.000–1.162) 0.049
Postoperative       
 MAP 0.962 (0.927–0.998) 0.038     
 The total amount of blood transfusion 1.077 (1.050–1.103)  < 0.001     
 Mechanical ventilation time 2.734 (1.903–3.928)  < 0.001     
 SOFA score 1.538 (1.283–1.845)  < 0.001     
 Hb 0.976 (0.957–0.995) 0.015     
 PLT 0.985 (0.977–0.993)  < 0.001     
 AKI 7.539 (1.709–33.251) 0.008     
 Advanced AKI 29.732 (11.507–76.821)  < 0.001 19.408 (6.553–57.482)  < 0.001 16.560 (5.154–53.212)  < 0.001
Use of CRRT 18.939 (6.485 – 55.313) 0.001     
Use of PE/BA 15.846 (1.848 – 135.879) 0.012     
Use of ECMO 22.270 (2.693–184.155) 0.004     
Peak TB concentration 1.018 (1.001–1.025)  < 0.001     
Peak direct bilirubin concentration 1.024 (1.015–1.033)  < 0.001     
Peak indirect bilirubin concentration 1.013 (1.001–1.026) 0.035     
Time to peak TB concentration 1.808 (1.458–2.242)  < 0.001 1.557 (1.259–1.926)  < 0.001   
Time to peak TB concentration ≥ 5 days 25.850 (10.218–65.399)  < 0.001    22.384 (6.767–74.035)  < 0.001
ICU stay time 1.285 (1.152–1.433)  < 0.001     
  1. ACC, aortic cross clamp; AKI, acute kidney injury; APACHEII, acute physiology and chronic health evaluation II; BA, bilirubin adsorption; CPB, cardiopulmonary bypass; CRRT, continuous renal replacement therapy; ECMO, extracorporeal membrane oxygenation; eGFR, estimated glomerular filtration rate; Hb, hemoglobin; ICU, intensive care unit; MAP, mean arterial pressure; PE, plasma exchange; PLT, platelet; SOFA, sequential organ failure assessment; TB, total bilirubin