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Table 3 Absolute and relative reduction in lipid levels and lipoprotein particle concentration compared to baseline after 8 weeks treatment

From: Effect of PCSK9 inhibitor on lipoprotein particles in patients with acute coronary syndromes

  Evolocumab + statins Statins
Week 8 Change from baseline Percent change from baseline (%) Week 8 Change from baseline Percent change from baseline (%)
VLDL-C (mg/dl) Total 17.2 ± 7.3 14.7 ± 15.4 26 20.0 ± 12.1 5.2 ± 12.9 7.9
 VLDL1 6.7 ± 4.6 6.1 ± 9.1 26.3 6.5 ± 4.5 3.5 ± 6.6 21.6
 VLDL2 + 3 2.6 ± 1.5 2.8 ± 2.7 20.4 3.6 ± 2.5 0.6 ± 2.3 − 20
 VLDL4 + 5 1.9 ± 1.3 2.2 ± 2.5 40.9 2.9 ± 2.3 0.6 ± 1.7 2.8
IDL-C (mg/dl) 5.7 ± 4.1 10.0 ± 7.9 62.0 9.3 ± 4.7 4.3 ± 6.4 20.7
LDL-C (mg/dl) Total 43.8 ± 21.8 81.6 ± 28.7 65.3 80.7 ± 14.8 22.9 ± 25.1 18.1
 LDL1 + 2 10.4 ± 4.3 9.6 ± 8.5 40.4 11.3 ± 4.6 4.2 ± 5.7 21.2
 LDL3 + 4 7.0 ± 4.9 10.2 ± 9.4 50.3 11.1 ± 4.5 2.4 ± 5.9 − 20.7
 LDL5 + 6 5.0 ± 5.6 21.2 ± 12.7 79.5 17.6 ± 5.9 5.4 ± 7.4 6.6
HDL-C (mg/dl) Total 46.9 ± 8.3 − 2.9 ± 6.5 − 7.6 44.8 ± 8.3 − 0.4 ± 9.0 − 3.4
 HDL1 + 2 10.2 ± 4.4 0.7 ± 3.6 − 2.2 10.5 ± 4.2 0.1 ± 2.6 − 2.7
 HDL3 + 4 12.6 ± 5.4 − 1.9 ± 3.2 − 82.7 11.3 ± 5.3 − 0.6 ± 4.1 27.2
TC (mg/dl) 109.9 ± 27.9 106.0 ± 37.8 48.4 153.7 ± 18.4 35.9 ± 33.7 16.9
VLDL-P (nmol/l) 158.2 ± 56.9 80.2 ± 84.8 19.1 165.5 ± 80.3 17.4 ± 79.5 − 1.2
IDL-P (nmol/l) 37.4 ± 22.1 54.0 ± 45.2 53.3 60.7 ± 28.8 27.8 ± 31.9 24.5
LDL-P (nmol/l) Total 463.6 ± 246.7 1128.9 ± 374.6 71 985.2 ± 203.3 332.5 ± 32.6 21.7
 LDL1 + 2 113.5 ± 40.1 91.4 ± 81.3 38.33 120.4 ± 45 40.5 ± 54.1 14.5
 LDL3 + 4 80.1 ± 52.7 119.8 ± 98.9 57.3 129.5 ± 45 32.5 ± 67.3 − 16.7
 LDL5 + 6 70.9 ± 76.8 304.8 ± 192.1 76.8 246.4 ± 91.8 83.0 ± 99.4 13.3
Lp(a) (nmol/l) 57.5(5.2,72.8) 15.6(8.5,29.5) 21.1 42.6(8.9,62.8) − 13.9(− 19.2,− 0.3) − 42.5
ApoB 42.3 ± 14.8 67.5 ± 23.6 60.9 71.5 ± 14.0 21.5 ± 20.2 20.8
LDL-C:HDL-C ratio 0.9 ± 0.4 2.0 ± 0.8 67.3 1.9 ± 0.5 0.5 ± 0.7 18.3
Apo-B:Apo-A1 ratio 0.3 ± 0.1 0.6 ± 0.2 63.3 0.6 ± 0.1 0.2 ± 0.2 21.4
LDL-P size 20.9 ± 0.5 − 0.7 ± 0.6 − 3.6 20.2 ± 0.2 0.0 ± 0.1 0.0