Fig. 2
![Fig. 2](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12872-020-01819-0/MediaObjects/12872_2020_1819_Fig2_HTML.png)
Pathway enrichment analysis. a Top 20 clusters with the smallest p value of upregulated mRNAs/proteins; b Top 20 clusters with the smallest p value of downregulated mRNAs/proteins right. The right part displays the network of selected enriched terms. Each term is represented by a circle node, where its size is proportional to the number of input genes that fall into that term, and its color represents its cluster identity (i.e., nodes of the same color belong to the same cluster). Terms with a similarity score > 0.3 are linked by an edge (the thickness of the edge represents the similarity score)