Analysis for interaction between interleukin-35 genes polymorphisms and risk factors on susceptibility to coronary heart disease in the Chinese Han population

Table 4 GMDR analysis for the best interaction combination models

Locus no	Best combination	Cross-validation consistency	Testing balanced accuracy	p-values^a
Gene–gene interactions^a
2	1, 3	7/10	0.607	0.321
3	1, 3, 2	6/10	0.532	0.528
4	1, 2, 4, 3	7/10	0.496	0.625
Gene–alcohol consumption interactions^b
2	1, 5	8/10	0.491	0.624
3	1, 2, 5	7/10	0.526	0.425
4	1, 2, 3, 5	5/10	0.518	0.746
5	1, 2, 3, 4, 5	6/10	0.521	0.857
Gene–smoking interactions^c
2	1, 6	10/10	0.632	0.010
3	1, 2, 6	7/10	0.532	0.172
4	1, 2, 3, 6	6/10	0.515	0.324
5	1, 2, 3, 4, 6	7/10	0.512	0.425

rs428253, rs4740, rs2243115, rs568408, current alcohol consumption and current smoking were symbolized as 1–6, respectively
^aAdjusted for age, gender, BMI, hypertension, T2DM, smoking and alcohol consumption
^bAdjusted for age, gender, BMI, hypertension, T2DM and smoking
^cAdjusted for age, gender, BMI, hypertension, T2DM and alcohol consumption

ISSN: 1471-2261