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Table 4 GMDR analysis for the best interaction combination models

From: Analysis for interaction between interleukin-35 genes polymorphisms and risk factors on susceptibility to coronary heart disease in the Chinese Han population

Locus no Best combination Cross-validation consistency Testing balanced accuracy p-valuesa
Gene–gene interactionsa    
 2 1, 3 7/10 0.607 0.321
 3 1, 3, 2 6/10 0.532 0.528
 4 1, 2, 4, 3 7/10 0.496 0.625
Gene–alcohol consumption interactionsb
 2 1, 5 8/10 0.491 0.624
 3 1, 2, 5 7/10 0.526 0.425
 4 1, 2, 3, 5 5/10 0.518 0.746
 5 1, 2, 3, 4, 5 6/10 0.521 0.857
Gene–smoking interactionsc
 2 1, 6 10/10 0.632 0.010
 3 1, 2, 6 7/10 0.532 0.172
 4 1, 2, 3, 6 6/10 0.515 0.324
 5 1, 2, 3, 4, 6 7/10 0.512 0.425
  1. rs428253, rs4740, rs2243115, rs568408, current alcohol consumption and current smoking were symbolized as 1–6, respectively
  2. aAdjusted for age, gender, BMI, hypertension, T2DM, smoking and alcohol consumption
  3. bAdjusted for age, gender, BMI, hypertension, T2DM and smoking
  4. cAdjusted for age, gender, BMI, hypertension, T2DM and alcohol consumption